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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast
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Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast

机译:Hsp82的两个真核生物特异性区域因其在酵母中的生存力和信号转导功能而不可或缺

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摘要

The 90-kDa heat shock protein (Hsp90) is a molecular chaperone that is very abundant even at normal temperature. It is highly conserved and essential for viability in yeast. To delineate functional domains of Hsp90, we have performed a deletion analysis of one of the two Hsp90 isoforms from budding yeast, Hsp82. The Hsp82 derivatives were tested for complementation of a Hsp90-deficient yeast strain and for their ability to function in two signal transduction pathways that depend on Hsp90.
机译:90 kDa热激蛋白(Hsp90)是一种分子伴侣,即使在常温下也非常丰富。它是高度保守的,对于酵母的生存力至关重要。为了描述Hsp90的功能域,我们已经对来自萌芽酵母Hsp82的两个Hsp90同工型之一进行了缺失分析。测试了Hsp82衍生物对Hsp90缺陷型酵母菌株的互补作用,以及它们在取决于Hsp90的两个信号转导途径中的功能。

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