Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin

William E. Royer Jr.; Animesh Pardanani; Quentin H. Gibson

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Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin

机译：有序水分子作为合作二聚体血红蛋白中的关键变构介体

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One of the most remarkable structural as- ects of Scapharca dimeric hemoglobin is the disruption of a very well-ordered water cluster at the subunit interface upon ligand binding. We have explored the role of these crystallo- raphically observed water molecules by site-directed mu- agenesis and osmotic stress techniques. The isosteric muta- ion of Thr-72 - Val in the interface increases oxygen affinity more than 40-fold with a surprising enhancement of cooperativity.

机译：Scapharca二聚体血红蛋白最显着的结构方面之一是在配体结合后破坏了亚单元界面上秩序井然的水团簇。我们已经通过定点诱变和渗透胁迫技术探索了这些晶体学上观察到的水分子的作用。界面上的Thr-72-Val的等位突变使氧亲和力增加了40倍以上，并且协同性显着提高。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第25期|p.14526-14531|共6页
作者
William E. Royer Jr.; Animesh Pardanani; Quentin H. Gibson;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Allosteric action in real time: Time-resolved crystallographic studies of a cooperative dimeric hemoglobin [J] . Knapp JE, Pahl R, Srajer V, Proceedings of the National Academy of Sciences of the United States of America . 2006,第20期

机译：实时变构作用：合作二聚体血红蛋白的时间分辨晶体学研究
2. Mutational destabilization of the critical interface water cluster in Scapharca dimeric hemoglobin: Structural basis for altered allosteric activity [J] . Pardanani A., Ascoli F., Royer WE., Journal of Molecular Biology . 1998,第3期

机译：Scapharca二聚体血红蛋白中关键界面水簇的突变失稳：变构活性改变的结构基础
3. Residue F4 Plays a Key Role in Modulating Oxygen Affinity and Cooperativity in Scapharca Dimeric Hemoglobin [J] . James E.Knapp, Michele A.Bonham, Quentin H.Gibson, Biochemistry . 2005,第44期

机译：残基F4在Scapharca二聚体血红蛋白的氧亲和力和协同性调节中起关键作用
4. An Electrochemical Engineering Perspective of Nitric Oxide in Tumors: Why the Combination of an Allosteric Effector of Hemoglobin with Dietary Sodium Nitrite Should Be Effective in Treating Vascularized Tumors? [C] . Adam Heller Electrochemistry in medicine and biomedical applications . 2010

机译：肿瘤中一氧化氮的电化学工程观点：为什么将血红蛋白的变构效应物与饮食亚硝酸钠联合使用可有效治疗血管化肿瘤？
5. X-RAY CRYSTALLOGRAPHIC STUDIES OF MONOMERIC AND DIMERIC HEMOGLOBINS FROM THE SEA CUCUMBER MOLPADIA ARENICOLA. [D] . CARSON, WILLIAM MICHAEL. 1980

机译：海黄瓜莫桑比克阿尼尼科拉的单和二元血红蛋白的X射线晶体学研究。
6. Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin [O] . William E. Royer Jr., Animesh Pardanani, Quentin H. Gibson, 1996

机译：有序的水分子是分子中的关键变构介体合作二聚体血红蛋白
7. Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin [O] . W. E. Royer, A. Pardanani, Q. H. Gibson, 1996

机译：命令水分子作为合作二聚体血红蛋白中的关键渐变介质

Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin

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