The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2

V. Porciatti; T. Pizzorusso; M. C. Cenni

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The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2

机译：在过表达Bcl-2的转基因小鼠中，视神经横断未改变视网膜神经节细胞的视觉反应

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Attempts to rescue retinal ganglion cells from retrograde degeneration have had limited success, and the residual function of surviving neurons is not known. Recently, it has been found that axotomized retinal ganglion cells die by apoptotic mechanisms. We have used adult trans- genic mice overexpressing the Bcl-2 protein, a powerful in- hibitor of apoptosis, as a model for preventing injury-induced cell death in vivo. Several months after axotomy, the majority of retinal ganglion cells survived and exhibited normal visual responses. In control wild-type mice, the vast majority of axotomized retinal ganglion cells degenerated, and the phys- iological responses were abolished.

机译：挽救视网膜神经节细胞免于逆行变性的尝试取得了有限的成功，尚不清楚存活的神经元的残余功能。最近，已经发现轴突切除的视网膜神经节细胞通过凋亡机制而死亡。我们已经使用过表达Bcl-2蛋白（一种强大的凋亡抑制剂）的成年转基因小鼠作为预防体内损伤诱导的细胞死亡的模型。轴切术后几个月，大多数视网膜神经节细胞存活并显示出正常的视觉反应。在对照野生型小鼠中，大多数无轴索化的视网膜神经节细胞退化，并且生理反应被消除。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第25期|p.14955-14959|共5页
作者
V. Porciatti; T. Pizzorusso; M. C. Cenni;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：神经纤维层退化和视网膜神经节细胞损失长期视神经粉碎或成人小鼠横断（Vol 170，PG 40，2018）
2. Nerve fibre layer degeneration and retinal ganglion cell loss long term after optic nerve crush or transection in adult mice* [J] . Sanchez-Migallon M. C., Valiente-Soriano F. J., Salinas-Navarro M., Experimental Eye Research . 2018,第期

机译：神经纤维层退化和视网膜神经节细胞损失长期后视神经挤压或成年小鼠的横伤*
3. Effects of pinealectomy and melatonin on the retrograde degeneration of retinal ganglion cells in a novel model of intraorbital optic nerve transection in mice. [J] . Kilic E, Hermann DM, Isenmann S, Journal of pineal research . 2002,第2期

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4. Optic nerve and retinal electrostimulation in rats: direct activation of the retinal ganglion cells [C] . Alejandro Barriga-Rivera, Gregg J. Suaning, Jose M. Delgado-Garcia, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2018

机译：大鼠视神经和视网膜电刺激：视网膜神经节细胞的直接激活
5. In vivo effects of single or combined topical neuroprotective and regenerative agents on degeneration of retinal ganglion cells in rat optic nerve crush model [D] . KITAMURA, Yuta 2019

机译：单一或联合使用局部神经保护和再生剂对大鼠视神经挤压模型中视网膜神经节细胞变性的体内作用
6. The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2 [O] . V. Porciatti, T. Pizzorusso, M. C. Cenni, 1996

机译：视网膜神经节细胞的视觉反应不会被改变转基因小鼠Bcl-2过表达中的视神经横切
7. The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2 [O] . V. Porciatti, T. Pizzorusso, M. C. Cenni, 1996

机译：视网膜神经节细胞的视觉响应不会通过转基因小鼠的视神经横闭改变，其过表达BCL-2

The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2

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