Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding

Hao Wu; David G. Myszka; Susan W. Tendian

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Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding

机译：艾滋病毒gp120结合缺陷的突变CD4受体的动力学和结构分析

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The T-cell antigen coreceptor CD4 also serves as the receptor for the envelope glycoprotein gp120 of HIV. Extensive mutational analysis of CD4 has implicated residues from a portion of the extracellular amino-terminal domain (D1) in gp120 binding. However, none of these pro- teins has been fully characterized biophysically, and thus the precise effects on molecular structure and binding interac- tions are unknown. In the present study, we produced soluble versions of three mutant CD4 molecules (F43V, G47S, and A55F) and characterized their structural properties, thermo- stability, and ability to bind gp120.

机译：T细胞抗原共受体CD4还充当HIV包膜糖蛋白gp120的受体。 CD4的广泛突变分析已牵连gp120结合中一部分细胞外氨基末端结构域（D1）的残基。但是，这些蛋白都没有在生物学上被完全表征，因此对分子结构和结合相互作用的精确作用尚不清楚。在本研究中，我们生产了三种突变CD4分子（F43V，G47S和A55F）的可溶形式，并表征了它们的结构特性，热稳定性和结合gp120的能力。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第26期|p.15030-15035|共6页
作者
Hao Wu; David G. Myszka; Susan W. Tendian;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure. [J] . U Moebius, L K Clayton, S Abraham, The Journal of Experomental Medicine . 1992,第2期

机译：CD4上的人类免疫缺陷病毒gp120结合位点：通过定量平衡和动力学结合研究突变体以及高分辨率CD4原子结构来进行描述。
2. Binding of full-length HIV-1 gp120 to CD4 induces structural reorientation around the gp120 core. [J] . Ashish, Garg R, Anguita J, Biophysical Journal . 2006,第6期

机译：全长HIV-1 gp120与CD4的结合会引起gp120核心周围的结构重新定向。
3. Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding [J] . Ruimin Pan, Yuxin Chen, Michael Vaine, Emerging microbes & infections. . 2015,第7期

机译：针对受体和共受体结合至关重要的HIV-1 gp120 C4区表位的新型兔单克隆抗体R53的结构分析
4. NMR STRUCTURAL ANALYSIS OF THE HIV-1 GP120 V3 - CCR5 CO-RECEPTOR N-TERMINAL INTERACTION [C] . Petros A. Galanakis, Nikolaos Kandias, Georgios A. Spyroulias the European Peptide Symposium . 2007

机译：HIV-1 GP120 V3 - CCR5共受体N末端相互作用的NMR结构分析
5. Somatic cell and molecular genetic analysis of various Chinese hamster ovary (CHO) mutant cells defective in sterol-dependent regulation of cholesterol biosynthesis and LDL receptor expression. [D] . Hasan, Mazahir Tahir. 1993

机译：各种中国仓鼠卵巢（CHO）突变细胞的体细胞和分子遗传学分析，它们在胆固醇依赖的胆固醇生物合成和LDL受体表达调控中存在缺陷。
6. Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding [O] . Hao Wu, David G. Myszka, Susan W. Tendian, 1996

机译：突变的CD4受体的动力学和结构分析 HIV gp120结合缺陷
7. Structural and kinetic analysis of CD4 mutants that are defective in HIV binding [O] . H. Wu, D. G. Myszka, S. W. Tendian, 1996

机译：HIV结合有缺陷的CD4突变体的结构和动力学分析

Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding

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