Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

Patrizia Farci; Atsushi Shimoda; Doris Wong

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Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

机译：通过针对包膜2蛋白高变区1的超免疫血清预防黑猩猩感染丙型肝炎病毒

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The identification of the neutralization do- mains of hepatitis C virus (HCV) is essential for the devel- opment of an effective vaccine. Here, we show that the hypervariable region 1 (HVR1) of the envelope 2 (E2) protein is a critical neutralization domain of HCV. Neutralization of HCV in vitro was attempted with a rabbit hyperimmune serum raised against a homologous synthetic peptide derived from the HVR1 of the E2 protein, and the residual infectivity was evaluated by inoculation of HCV-seronegative chimpanzees.

机译：丙型肝炎病毒（HCV）中和作用域的确定对于开发有效疫苗至关重要。在这里，我们显示包膜2（E2）蛋白的高变区1（HVR1）是HCV的关键中和域。尝试使用针对源自E2蛋白HVR1的同源合成肽的兔超免疫血清在体外中和HCV，并通过接种HCV血清阴性黑猩猩评估残留的感染性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第26期|p.15394-15399|共6页
作者
Patrizia Farci; Atsushi Shimoda; Doris Wong;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Prevention of hepatitis C virus infection in a chimpanzee by vaccination and epitope mapping of antiserum directed against hypervariable region 1. [J] . Goto J, Esumi M, Rikihisa T, Hepatology research: the official journal of the Japan Society of Hepatology . 2001,第3期

机译：通过针对高变区1的抗血清的疫苗接种和抗原决定部位定位来预防黑猩猩中的丙型肝炎病毒感染。
2. Sequences in the hypervariable region 1 of hepatitis C virus show only minimal variability in the presence of antibodies against hypervariable region 1 during acute infection in chimpanzees Brief Report. [J] . Zhou YH, Sugitani M, Esumi M Archives of virology . 2002,第10期

机译：在黑猩猩的急性感染过程中，丙型肝炎病毒高变区1中的序列在抗高变区1抗体存在下仅表现出最小的变异性。
3. Sequences in the hypervariable region 1 of hepatitis C virus show only minimal variability in the presence of antibodies against hypervariable region 1 during acute infection in chimpanzees Brief Report. [J] . Zhou YH, Sugitani M, Esumi M Archives of virology . 2002,第10期

机译：在黑猩猩的急性感染过程中，丙型肝炎病毒高变区1中的序列在针对高变区1的抗体存在下仅显示出最小的变异性。
4. Variation in physicochemical properties of the hypervariable region 1 during acute and chronic stages of hepatitis C virus infection [C] . Astrakhantseva I. V., Campo D. S., Araujo A., 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops . 2011

机译：丙型肝炎病毒感染的急慢性阶段高变区1的理化特性变化
5. Regulation of amplification of cccDNA in hepatitis B virus: Involvement of the viral envelope proteins. [D] . Lentz, Thomas B. 2011

机译：乙型肝炎病毒中cccDNA扩增的调控：病毒包膜蛋白的参与。
6. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein [O] . Patrizia Farci, Atsushi Shimoda, Doris Wong, 1996

机译：预防黑猩猩感染丙型肝炎病毒针对小鼠高变区1的超免疫血清包膜2蛋白
7. Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees [O] . Forns, Xavier, Thimme, Robert, Govindarajan, Sugantha, 2000

机译：缺乏丙型肝炎高变区1的丙型肝炎病毒第二包膜蛋白具有感染性，可引起急性分离或黑猩猩的持续感染

Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

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