Regeneration of broken tip links and restoration of mechanical transduction in hair cells

Yi-dong Zhao; Ebenezer N. Yamoah; Peter G. Gillespie

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Regeneration of broken tip links and restoration of mechanical transduction in hair cells

机译：断裂的尖端连接的再生和毛细胞中机械转导的恢复

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A hair cell's tip links are thought to gate mechanoelectrical transduction channels. The susceptibility of tip links to acoustic trauma raises questions as to whether these fragile structures can be regenerated. We broke tip links with the calcium chelator 1,2-bis(O-aminophenoxy)ethane- N,N,N',N''-tetraacetic acid and found that they can regener- ate, albeit imperfectly, over several hours. The time course of tip-link regeneration suggests that this process may underlie recovery from temporary threshold shifts induced by noise exposure.

机译：毛细胞的尖端链接被认为可以控制机电转换通道。尖端链接对声音创伤的敏感性引发了关于这些脆弱结构是否可以再生的疑问。我们断开了与钙螯合剂1,2-双（O-氨基苯氧基）乙烷-N，N，N'，N''-四乙酸的尖端连接，发现它们可以在数小时内再生，尽管不完美。尖端链接再生的时间过程表明，此过程可能是由噪声暴露引起的临时阈值偏移恢复的基础。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第26期|p.15469-15474|共6页
作者
Yi-dong Zhao; Ebenezer N. Yamoah; Peter G. Gillespie;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Hair cell stereociliary bundle regeneration by espin gene transduction after aminoglycoside damage and hair cell induction by Notch inhibition [J] . Taura A., Taura K., Koyama Y., Gene therapy . 2016,第5期

机译：氨基糖苷损伤后通过espin基因转导的毛细胞立体纤毛束再生和Notch抑制诱导的毛细胞
2. HAIR CELL MECHANO-TRANSDUCTION - ITS INFLUENCE ON THE GROSS MECHANICAL CHARACTERISTICS OF A HAIR CELL SENSE ORGAN [J] . Vannetten SM. Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 1997,第1a3期

机译：毛细胞的传递-对毛细胞感觉器官的力学特性的影响。
3. Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel [J] . MarcottiW., CornsL.F., DesmondsT., The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2014,第16期

机译：耳蜗毛细胞中无尖端连接的转导是由离子通道介导的，其离子通道的渗透特性不同于机电转换器通道的渗透特性
4. A membrane bending mechanism for nanoelectromechanical transduction in cochlear outer hair cells [C] . Robert M. Raphael Bioengineering Conference . 2001

机译：耳蜗外毛细胞纳米机电转导的膜弯曲机制
5. Structural features of hair bundle polarity during hair cell regeneration. [D] . Bennett, Heather Leigh. 2007

机译：毛细胞再生过程中毛束极性的结构特征。
6. Regeneration of broken tip links and restoration of mechanical transduction in hair cells [O] . Yi-dong Zhao, Ebenezer N. Yamoah, Peter G. Gillespie 1996

机译：断裂的尖端连杆的再生和机械的恢复毛细胞内转导
7. Regeneration of broken tip links and restoration of mechanical transduction in hair cells [O] . Y.-d. Zhao, E. N. Yamoah, P. G. Gillespie 1996

机译：破碎尖端链路的再生和毛细胞机械转导的恢复
8. Comparative transduction mechanisms of hair cells in the bullfrog uticulus. 2: Sensitivity and response dynamics to hair bundle displacement [R] . Baird, Richard A. 1994

机译：牛蛙细胞毛细胞的比较转导机制。 2：对发束位移的敏感性和响应动力学

Regeneration of broken tip links and restoration of mechanical transduction in hair cells

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