Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

Nabors GS; Afonso LC; Farrell JP; Scott P

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

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Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

机译：通过将白介素12和Pentostam联合治疗，可诱导小鼠从2型T型辅助细胞转换为1型T辅助细胞反应并治愈已建立的利什曼原虫主要感染。

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Successful treatment in allergic, autoimmune, and infectious diseases often requires altering the nature of a detrimental immune response mediated by a particular CD4+ T helper (Th) cell subset. While several factors contribute to the development of CD4+ Th1 and Th2 cells, the requirements for switching an established response are not understood. Here we use infection with Leishmania major as a model to investigate those requirements. We report that treatment with interleukin 12 (IL-12), in combination with the antimony-based leishmanicidal drug Pentostam, induces healing in L. major-infected mice and that healing is associated with a switch from a Th2 to a Th1 response. The data suggest that decreasing antigen levels may be required for IL-12 to inhibit a Th2 response and enhance a Th1 response. These observations are important for treatment of nonhealing forms of human leishmaniasis and also demonstrate that in a chronic infectious disease an inappropriate Th2 response can be switched to an effectiveTh1 response.

机译：成功地治疗变态反应，自身免疫和传染病通常需要改变由特定CD4 + T辅助（Th）细胞亚群介导的有害免疫反应的性质。尽管有几个因素有助于CD4 + Th1和Th2细胞的发育，但尚未理解转换既定反应的要求。在这里，我们以大利什曼原虫感染为模型来研究这些需求。我们报告说，白介素12（IL-12）与基于锑的利什曼杀菌药Pentostam结合治疗，可在L.major感染的小鼠中诱导愈合，并且该愈合与从Th2反应转变为Th1反应有关。数据表明，IL-12抑制Th2反应并增强Th1反应可能需要降低抗原水平。这些观察对于治疗人类利什曼病的非治愈形式很重要，并且还表明在慢性感染性疾病中，不适当的Th2反应可以转换为有效的Th1反应。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第8期|P.3142-3146|共5页
作者
Nabors GS; Afonso LC; Farrell JP; Scott P;
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作者单位

Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Antimony Sodium Gluconate; Interleukin-12; Leishmaniasis; Cutaneous; T-Lymphocytes; Helper-Inducer; 葡萄酸锑钠; 白细胞介素12; 利什曼病; 皮肤; T淋巴细胞; 辅助诱导;

机译：Antimony Sodium Gluconate;Interleukin-12;Leishmaniasis;Cutaneous;T-Lymphocytes;Helper-Inducer;葡萄酸锑钠;白细胞介素12;利什曼病;皮肤;T淋巴细胞;辅助诱导;

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专利

1. KM(+), a lectin from Artocarpus integrifolia, induces IL-12 p40 production by macrophages and switches from type 2 to type 1 cell-mediated immunity against Leishmania major antigens, resulting in BALB/c mice resistance to infection. [J] . Panunto-Castelo A, Souza MA, Roque-Barreira MC, Glycobiology. . 2001,第12期

机译：KM（+）是一种来自面包果的凝集素，可诱导巨噬细胞分泌IL-12 p40，并将其针对利什曼原虫主要抗原的2型细胞介导的免疫转换为1型细胞介导的免疫，从而导致BALB / c小鼠对感染的抵抗力。
2. Combined Treatment with Interleukin-12 and Indomethacin Promotes Increased Resistance in BALB/c Mice with Established Leishmania major Infections [J] . Jian Li, Udaikumar M. Padigel, Phillip Scott, Infection and immunity . 2002,第10期

机译：白细胞介素12和消炎痛的联合治疗可促进已建立利什曼原虫主要感染的BALB / c小鼠的耐药性增加
3. Combined Treatment with Interleukin-12 and Indomethacin Promotes Increased Resistance in BALB/c Mice with Established Leishmania major Infections [J] . Jian Li, Udaikumar M. Padigel, Phillip Scott, Infection and immunity . 2002,第10期

机译：白细胞介素12和消炎痛的联合治疗可促进已建立利什曼原虫主要感染的BALB / c小鼠的耐药性增加
4. Cell-Type-Dependent Effect of Transforming Growth Factor-beta, a Major Cytokine in Breast Milk, on Human Immunodeficiency Virus Type 1 Infection of Mammary Epithelial MCF-7 Cells or Macrophages [C] . M. Moriuchi, H. Moriuchi International AIDS Conference . 2004

机译：转化生长因子-β，母乳中主要细胞因子的细胞型依赖性效应，对人免疫缺陷病毒1型感染乳腺上皮MCF-7细胞或巨噬细胞
5. Human cytomegalovirus reactivation following seasonal allergen exposure and switch to T-helper cell type 2 profile [D] . Dumont, Larry Joe 2005

机译：季节性变应原暴露后人类巨细胞病毒重新激活并转换为2型T辅助细胞
6. Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. [O] . G S Nabors, L C Afonso, J P Farrell, 1995

机译：通过将白介素12和Pentostam联合治疗可诱导小鼠从2型T型辅助细胞转换为1型T辅助细胞反应并治愈已建立的利什曼原虫主要感染。
7. Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. [O] . Nabors, G S, Afonso, L C, Farrell, J P, 1995

机译：通过将白介素12和Pentostam联合治疗，可诱导小鼠从2型T型辅助细胞转换为1型T辅助细胞反应并治愈已建立的利什曼原虫主要感染。
8. Establishment of an Inbred Line of Mice that Express a Synergistic Immune Detect Precluding In Vitro Responses to Type 1 and Type 2 Antigens, B Cell Mitogens, and a Number of T Cell-Derived helper Factors [R] . Mond, J. J., Norton, G., Paul, W. E., 1983

机译：建立表达协同免疫检测的小鼠近交系，预防1型和2型抗原，B细胞mitogens和一些T细胞衍生辅助因子的体外反应

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

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