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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mos overexpression in Swiss 3T3 cells induces meiotic-like alterations of the mitotic spindle.
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Mos overexpression in Swiss 3T3 cells induces meiotic-like alterations of the mitotic spindle.

机译：Mos在Swiss 3T3细胞中的过度表达诱导有丝分裂纺锤体的减数分裂样改变。

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摘要

High levels of mos protooncogene product are expressed during oocyte meiotic maturation and Mos has been implicated in formation of the spindle and spindle pole. Here, we show that in Swiss 3T3 cells with 4N DNA content, high levels of Mos lead to the production of binucleated cells. The Swiss 3T3 cells in mitosis, before binucleation occurs, are anastral and the spindle poles are juxtaposed to the cell membrane. These phenotypes may be related to the meiotic process of attachment of the spindle pole to the oocyte membrane during polar body formation. The production of binucleated somatic cells could result from attachment of the altered mitotic spindle pole to the cell membrane that interferes with cytokinesis but not karyokinesis. This can explain at least one form of genetic instability that leads to altered DNA content in tumor cells.
机译：在卵母细胞减数分裂成熟期间表达高水平的mos原癌基因产物，并且Mos与纺锤体和纺锤体极的形成有关。在这里，我们显示在具有4N DNA含量的瑞士3T3细胞中，高水平的Mos导致产生双核细胞。在双核化发生之前，处于有丝分裂状态的Swiss 3T3细胞是吻合的，纺锤极与细胞膜并置。这些表型可能与极体形成过程中纺锤体极附着在卵母细胞膜上的减数分裂过程有关。双核体细胞的产生可能是由于改变后的有丝分裂纺锤体极附着在细胞膜上而干扰了细胞分裂，但不影响核运动。这可以解释至少一种形式的遗传不稳定性，其导致肿瘤细胞中DNA含量的改变。

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