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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Basic fibroblast growth factor can mediate the early inductive events in renal development.
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Basic fibroblast growth factor can mediate the early inductive events in renal development.

机译：碱性成纤维细胞生长因子可以介导肾脏发育的早期诱导事件。

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摘要

The earliest characterized events during induction of tubulogenesis in renal anlage include the condensation or compaction of metanephrogenic mesenchyme with the concurrent upregulation of WT1, the gene encoding the Wilms tumor transcriptional activator/suppressor. We report that basic fibroblast growth factor (FGF2) can mimic the early effects of an inductor tissue by promoting the condensation of mesenchyme and inhibiting the tissue degeneration associated with the absence of an inductor tissue. By in situ hybridization, FGF2 was also found to mediate the transcriptional activation of WT1 and of the hepatocyte growth factor receptor gene, c-met. Although FGF2 can induce these early events of renal tubulogenesis, it cannot promote the epithelial conversion associated with tubule formation in metanephrogenic mesenchyme. For this, an undefined factor(s) from pituitary extract in combination with FGF2 can cause tubule formation in uninduced mesenchyme. These findings support the concept that induction inkidney is a multiphasic process that is mediated by more than a single comprehensive inductive factor and that soluble molecules can mimic these inductive activities in isolated uninduced metanephrogenic mesenchyme.
机译：肾小管形成诱导过程中最早的特征性事件包括后肾上皮间充质的浓缩或紧缩以及同时上调WT1的上调，WT1是编码Wilms肿瘤转录激活因子/抑制因子的基因。我们报告说，碱性成纤维细胞生长因子（FGF2）可以通过促进间充质的凝结和抑制与不存在诱导剂组织相关的组织变性来模拟诱导剂组织的早期作用。通过原位杂交，还发现FGF2介导了WT1和肝细胞生长因子受体基因c-met的转录激活。尽管FGF2可以诱导这些肾小管生成的早期事件，但它不能促进与变肾原性间充质中小管形成相关的上皮转化。为此，来自垂体提取物与FGF2结合的不确定因素可导致未诱导的间充质中的小管形成。这些发现支持了这样的概念，即感应墨胺是一个多相过程，由多个单一的综合性诱导因子介导，可溶性分子可以在分离的未诱导的肾原性间充质中模拟这些诱导活性。

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