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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Lesion-induced reorganization in the brainstem is not completely expressed in somatosensory cortex.
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Lesion-induced reorganization in the brainstem is not completely expressed in somatosensory cortex.

机译:病变诱导的脑干重组未在体感皮层中完全表达。

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摘要

Electrophysiological and neuroanatomical methods were used to determine the extent to which neonatal forelimb removal altered the organization of the cuneate nucleus and representations of the fore- and hindlimbs in the primary somatosensory cortex of adult rats. Neonatal forelimb removal resulted in invasion of the cuneate nucleus by sciatic nerve primary afferents and development of cuneothalamic projection neurons with split receptive fields that included both the hindlimb and forelimb stump. Mapping in the primary somatosensory cortex of the neonatally manipulated adult rats demonstrated abnormalities, but the major change observed in the cuneate nucleus was demonstrable at only a few (5%) cortical recording sites in the remaining stump representation and there were none at all in the hindlimb representation. These results suggest that lesion-induced brainstem reorganization may be functionally suppressed at either the thalamic or cortical level.
机译:使用电生理学和神经解剖学方法来确定新生前肢去除在多大程度上改变了成年大鼠初级体感皮层的楔形核的组织以及前肢和后肢的表示。新生儿前肢的去除导致坐骨神经初级传入神经侵袭楔形核,并形成具有分离的感受野的丘脑丘脑投射神经元,包括后肢和前肢残端。新生的成年大鼠的初级体感皮层中的映射显示出异常,但在剩余残端表示中仅在少数(5%)皮质记录位点显示了楔形核中观察到的主要变化,并且在所有残端表示中都没有。后肢代表。这些结果表明,在丘脑或皮层水平上,病变诱导的脑干重组可能在功能上受到抑制。

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