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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Alterations in Notch signaling in neoplastic lesions of the human cervix.
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Alterations in Notch signaling in neoplastic lesions of the human cervix.

机译：人宫颈癌病变中Notch信号的变化。

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摘要

The development of cancer is a cellular process that reflects and is partly driven by alterations in cell determination. Mutations in various molecules responsible for cell determination have been identified as being oncogenic, but little is known about the involvement of normal cell fate-determining mechanisms in the oncogenic process. The Notch pathway defines an evolutionarily conserved, general cell interaction mechanism that controls fundamental aspects of cell determination during vertebrate and invertebrate development. We have explored the involvement of the human Notch pathway in human cervical tissues, which define a cellular environment where cell fate changes take place and where neoplastic conditions have been well characterized. Our evidence suggests that Notch expression is associated with cell populations that are undergoing cell fate changes and that Notch activity can be used to monitor cell fate abnormalities in cervical as well as other epithelial neoplasias.
机译：癌症的发展是一种细胞过程，反映并部分由细胞测定的改变驱动。已经鉴定出负责细胞确定的各种分子中的突变是致癌的，但对于正常细胞命运决定机制在致癌过程中的参与知之甚少。 Notch途径定义了一种进化上保守的，一般的细胞相互作用机制，该机制控制着脊椎动物和无脊椎动物发育过程中细胞测定的基本方面。我们已经探索了人类Notch途径参与人类宫颈组织的过程，人类宫颈组织定义了一个细胞环境，在该环境中细胞命运发生了变化，并且肿瘤状况得到了很好的表征。我们的证据表明，Notch表达与经历细胞命运变化的细胞群有关，并且Notch活性可用于监测子宫颈及其他上皮肿瘤的细胞命运异常。

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