Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.

DAngelo G; Struman I; Martial J; Weiner RI

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Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.

机译：催乳素的抗血管生成因子16-kDa N-末端片段可抑制毛细血管内皮细胞中血管内皮生长因子和碱性成纤维细胞生长因子对促分裂原活化蛋白激酶的激活。

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A number of factors both stimulating and inhibiting angiogenesis have been described. In the current work, we demonstrate that the angiogenic factor vascular endothelial growth factor (VEGF) activates mitogen-activated protein kinase (MAPK) as has been previously shown for basic fibroblast growth factor. The antiagiogenic factor 16-kDa N-terminal fragment of human prolactin inhibits activation of MAPK distal to autophosphorylation of the putative VEGF receptor, Flk-1, and phospholipase C-gamma. These data show that activation and inhibition of MAPK may play a central role in the control of angiogenesis.

机译：已经描述了许多刺激和抑制血管生成的因素。在当前的工作中，我们证明了血管生成因子血管内皮生长因子（VEGF）激活有丝分裂原激活的蛋白激酶（MAPK），正如先前对碱性成纤维细胞生长因子所显示的那样。人催乳素的抗血管生成因子16-kDa N端片段可抑制假定的VEGF受体，Flk-1和磷脂酶C-γ自身磷酸化远端的MAPK活化。这些数据表明，MAPK的激活和抑制可能在血管生成的控制中起着核心作用。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第14期|P.6374-6378|共5页
作者
DAngelo G; Struman I; Martial J; Weiner RI;
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作者单位

Reproductive Endocrinology Center, University of California School of Medicine, San Francisco 94143, USA.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Ca2+ Calmodulin Dependent Protein Kinase metabolism; Endothelial Growth Factors; 内皮生长因子; 内皮; 血管; 淋巴因子; 肽碎片; 催乳素;

机译：Ca2+ Calmodulin Dependent Protein Kinase metabolism;Endothelial Growth Factors;内皮生长因子;内皮;血管;淋巴因子;肽碎片;催乳素;

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专利

1. Basic fibroblast growth factor stimulates vascular endothelial growth factor release in osteoblasts: divergent regulation by p42/p44 mitogen-activated protein kinase and p38 mitogen-activated protein kinase. [J] . Tokuda H, Kozawa O, Uematsu T Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research . 2000,第12期

机译：碱性成纤维细胞生长因子刺激成骨细胞中血管内皮生长因子的释放：p42 / p44丝裂原活化蛋白激酶和p38丝裂原活化蛋白激酶的调控不同。
2. Role of platelet-derived growth factor-B, vascular endothelial growth factor, insulin-like growth factor-II, mitogen-activated protein kinase and transforming growth factor-beta1 in expansion-induced lung growth in fetal sheep [J] . Wallace MJ, Thiel AM, Lines AM, Reproduction, fertility, and development . 2006,第6期

机译：血小板衍生生长因子-B，血管内皮生长因子，胰岛素样生长因子-II，促分裂原活化蛋白激酶和转化生长因子-β1在扩张诱导的胎羊肺生长中的作用
3. Role of platelet-derived growth factor-B, vascular endothelial growth factor, insulin-like growth factor-II, mitogen-activated protein kinase and transforming growth factor-beta1 in expansion-induced lung growth in fetal sheep [J] . Wallace MJ, Thiel AM, Lines AM, Reproduction, fertility, and development . 2006,第6期

机译：血小板衍生生长因子-B，血管内皮生长因子，胰岛素样生长因子-II，促分裂原活化蛋白激酶和转化生长因子-β1在扩张诱导的胎羊肺生长中的作用
4. Constructing a Blood Vessel on the Porous Scaffold Modified with Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor [C] . V. V. Sevostyanova, V. G. Matveeva, L. V. Antonova, International Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures . 2016

机译：用血管内皮生长因子和碱性成纤维细胞生长因子修饰多孔支架上的血管
5. The mechanism of regulation of fibroblast growth factor-2 (fgf-2) and vascular endothelial growth factor-a (vegf-a) dependent angiogenesis by junctional adhesion molecule-a (jam-a). [D] . Chatterjee, Sharmila. 2013

机译：通过连接黏附分子-a（jam-a）调节成纤维细胞生长因子2（fgf-2）和血管内皮生长因子-a（vegf-a）依赖性血管生成的机制。
6. Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin. [O] . G DAngelo, I Struman, J Martial, 1995

机译：催乳素的抗血管生成因子16-kDa N-末端片段可抑制毛细血管内皮细胞中血管内皮生长因子和碱性成纤维细胞生长因子对促分裂原活化蛋白激酶的激活。
7. Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin. [O] . D'Angelo, G, Struman, I, Martial, J, 1995

机译：催乳素的抗血管生成因子16-kDa N-末端片段可抑制毛细血管内皮细胞中血管内皮生长因子和碱性成纤维细胞生长因子对促分裂原活化蛋白激酶的激活。

Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.

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