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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >ON THE EXISTENCE AND IMPLICATIONS OF AN INVERSE FOLDING CODE IN PROTEINS
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ON THE EXISTENCE AND IMPLICATIONS OF AN INVERSE FOLDING CODE IN PROTEINS

机译：蛋白质反折叠码的存在与含义

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摘要

The existence of a code relating the set of possible sequences at a given position in a protein backbone to the local structure at that location is investigated. It is shown that only 73% of 4-C-alpha structure fragments in a sample of 114 protein structures exhibit a preference for a particular set of sequences. The remaining structures can accommodate essentially any sequence. The structures that encode specific sequence distributions include the classical ''secondary'' structures, with the notable exception of planar (beta) bends. It is suggested that this has implications as to the mechanism of folding in proteins with extensive sheet/barrel structure. The possible role of structures that do not encode specific sequences as mutation hot spots is noted. [References: 14]
机译：研究了将蛋白质骨架中给定位置的一组可能序列与该位置的局部结构相关联的代码的存在。结果表明，在114种蛋白质结构的样品中，只有73％的4-C-α结构片段显示出对特定序列集的偏好。其余的结构基本上可以容纳任何顺序。编码特定序列分布的结构包括经典的“二级”结构，但平面（β）弯头除外。有人认为这与具有广泛的片/桶结构的蛋白质的折叠机制有关。指出了不编码特定序列作为突变热点的结构的可能作用。 [参考：14]

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