VIP21/CAVEOLIN IS A CHOLESTEROL-BINDING PROTEIN

Murata M.; Schreiner R.; Wieland F.; Kurzchalia TV.; Simons K.; Peranen J.

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VIP21/CAVEOLIN IS A CHOLESTEROL-BINDING PROTEIN

机译：VIP21 / CAVEOLIN是胆固醇结合蛋白

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MP21/caveolin is localized to both caveolae and apical transport vesicles and presumably cycles between the cell surface and the Golgi complex. We have studied the lipid interactions of this protein by reconstituting Escherichia coli-expressed VIP21/caveolin into liposomes. Surprisingly, the protein reconstituted only with cholesterol-containing lipid mixtures. We demonstrated that the protein binds at least 1 mol of cholesterol per mole of protein and that this binding promotes formation of protein oligomers. These findings suggest that VIP21/caveolin, through its cholesterol-binding properties, serves a specific function in microdomain formation during membrane trafficking. [References: 30]

机译：MP21 / caveolin定位于小窝和顶端运输囊泡，大概在细胞表面和高尔基体之间循环。我们已经通过将大肠杆菌表达的VIP21 /小孔蛋白重构为脂质体来研究该蛋白的脂质相互作用。出人意料的是，该蛋白质仅与含胆固醇的脂质混合物一起重构。我们证明了该蛋白质与每摩尔蛋白质结合至少1摩尔胆固醇，并且这种结合促进蛋白质寡聚体的形成。这些发现表明，VIP21 / caveolin通过其胆固醇结合特性，在膜运输过程中的微区形成中起特定作用。 [参考：30]

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《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第22期|p. 10339-10343|共5页
作者
Murata M.; Schreiner R.; Wieland F.; Kurzchalia TV.; Simons K.; Peranen J.;
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作者单位

EUROPEAN MOLEC BIOL LAB CELL BIOL PROGRAMME MEYERHOFSTR 1 D-69117 HEIDELBERG GERMANY;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Membrane microdomains; Intracellular transport; Membrane reconstitution; Trans-golgi-network; Epithelial-cells; Membrane; Component; Caveolae; Invaginations; Receptor; Vesicles; Vip21;

机译：膜微区;细胞内运输;膜重构;反高尔基体网络;上皮细胞;膜;成分;腔洞;内陷;受体;囊泡;Vip21;

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专利

1. The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles [J] . Glenney John R. FEBS Letters . 1992,第1期

机译：人类小窝蛋白序列揭示了与运输小泡组分VIP21的同一性
2. VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. [J] . T V Kurzchalia, P Dupree, R G Parton, Journal of cell biology . 1992,第5期

机译：VIP21是一种21 kD的膜蛋白，是反式高尔基网络衍生的运输小泡的组成部分。
3. Storey, S.M.a , McIntosh, A.L.a , Huang, H.a , Landrock, K.K.a , Martin, G.G.a , Landrock, D.b , Ross Payne, H.b , Atshaves, B.P.a , Kier, A.B.b , Schroeder, F.a Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes [J] . American Journal of Physiology . 2012,第4aPta1期

机译：Storey，SMa，McIntosh，ALA，Huang，Ha，Landrock，KKa，Martin，GGa，Landrock，Db，Ross Payne，Hb，Atshaves，BPa，Kier，ABb，Schroeder，Fa细胞内胆固醇结合蛋白可增强HDL介导的胆固醇对原代小鼠肝细胞的摄取
4. Differential Analysis of Proteins from Caveolin-Rich Lipid Rafts in Primary and Metastatic Colorectal Cancer Clones [C] . Shirley S. Arielly, Matty Ariel, Rivka Yehuda, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：富含富含肝素的脂肪筏中蛋白质的差异分析，转移性结直肠癌克隆
5. Investigating Detergent and Lipid Systems for the Study of Membrane Protein Interactions: Characterizing Caveolin Oligomerization. [D] . Rieth, Monica D. 2014

机译：研究膜蛋白相互作用的洗涤剂和脂质系统：表征小孔寡聚体。
6. VIP21/caveolin is a cholesterol-binding protein. [O] . M Murata, J Peränen, R Schreiner, 1995

机译：VIP21 /小窝蛋白是一种胆固醇结合蛋白。
7. VIP21/caveolin is a cholesterol-binding protein. [O] . Murata, M, Peränen, J, Schreiner, R, 1995

机译：VIP21 /小窝蛋白是一种胆固醇结合蛋白。

VIP21/CAVEOLIN IS A CHOLESTEROL-BINDING PROTEIN

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