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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >AN ALTERNATIVE PATHWAY FOR SIGNAL FLOW FROM ROD PHOTORECEPTORS TO GANGLION CELLS IN MAMMALIAN RETINA
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AN ALTERNATIVE PATHWAY FOR SIGNAL FLOW FROM ROD PHOTORECEPTORS TO GANGLION CELLS IN MAMMALIAN RETINA

机译：哺乳动物视网膜中从杆状光感受器到神经节细胞的信号流的替代途径

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Rod signals in the mammalian retina are thought to reach ganglion cells over the circuit rod --> rod depolarizing bipolar cell --> All amacrine cell --> cone bipolar cells --> ganglion cells, A possible alternative pathway involves gap junctions linking the rods and cones, the circuit being rod --> cone --> cone bipolar cells --> ganglion cells, It is not clear whether this second pathway indeed relays rod signals to ganglion cells. We studied signal flow in the isolated rabbit retina with a multielectrode array, which allows the activity of many identified ganglion cells to be observed simultaneously while the preparation is stimulated with light and/or exposed to drugs, When transmission between rods and rod depolarizing bipolar cells was blocked by the glutamate agonist 2-amino-4-phosphonobutyric acid (APB), rod input to all On-center and briskly responding Off-center ganglion cells was dramatically reduced as expected. Off responses persisted, however, in Off-center sluggish and On-Off direction-selective ganglion cells, Presumably these responses were generated by the alternative pathway involving rod-cone junctions, This APE-resistant pathway may carry the major rod input to Off-center sluggish and On-Off direction-selective ganglion cells. [References: 34]
机译：哺乳动物视网膜中的杆信号被认为到达了电路杆上的神经节细胞->杆去极化双极细胞->所有无长突细胞->锥体双极细胞->神经节细胞，一种可能的替代途径涉及间隙连接杆和视锥细胞，回路是视杆->视锥细胞->视锥双极细胞->神经节细胞，尚不清楚第二条途径是否确实将视杆信号中继到神经节细胞。我们用多电极阵列研究了离体兔视网膜中的信号流，当在光刺激和/或暴露于药物的情况下，当杆和杆去极化双极细胞之间传播时，可以同时观察到许多已鉴定的神经节细胞的活性。被谷氨酸激动剂2-氨基-4-膦酰丁酸（APB）阻断，杆输入到所有在中心的和轻快响应的离中心神经节细胞都如预期的那样大大减少。 Off反应持续存在，但是，在偏心迟缓和On-Off方向选择性神经节细胞中，推测这些反应是由涉及杆-锥结的替代途径产生的。这种抗APE的途径可能会将主要的杆输入带到Off-中心迟缓和On-Off方向选择神经节细胞。 [参考：34]

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