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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >SEX AND THE SINGLE CELL - MEIOSIS IN YEAST [Review]
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SEX AND THE SINGLE CELL - MEIOSIS IN YEAST [Review]

机译：性和单细胞-酵母菌减数分裂[综述]

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摘要

Recent studies of Saccharomyces cerevisiae have significantly advanced our understanding of the molecular mechanisms of meiotic chromosome behavior. Structural components of the synaptonemal complex have been identified and studies of mutants defective in synapsis have provided insight into the role of the synaptonemal complex in homolog pairing, genetic recombination, crossover interference, and meiotic chromosome segregation, There is compelling evidence that most or all meiotic recombination events initiate with double-strand breaks. Several intermediates in the double-strand break repair pathway have been characterized and mutants blocked at different steps in the pathway have been identified. With the application of genetic, molecular, cytological, and biochemical methods in a single organism, we can expect an increasingly comprehensive and unified view of the meiotic process. [References: 93]
机译：酿酒酵母的最新研究大大提高了我们对减数分裂染色体行为的分子机制的了解。已经鉴定了突触复合物的结构成分，对突触缺陷型突变体的研究提供了对突触复合物在同源配对，遗传重组，交叉干扰和减数分裂染色体分离中的作用的深入了解。有力的证据表明，大多数或全部减数分裂重组事件以双链断裂开始。已经鉴定了双链断裂修复途径中的几种中间体，并且已经鉴定了在途径中不同步骤处被阻断的突变体。随着遗传，分子，细胞学和生化方法在单个生物体中的应用，我们可以期望对减数分裂过程的了解越来越全面和统一。 [参考：93]

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