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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >THE BALB/C MOUSE B-CELL RESPONSE TO PIGEON CYTOCHROME C INITIATES AS A HETEROCLITIC RESPONSE SPECIFIC FOR THE SELF ANTIGEN MOUSE CYTOCHROME C
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THE BALB/C MOUSE B-CELL RESPONSE TO PIGEON CYTOCHROME C INITIATES AS A HETEROCLITIC RESPONSE SPECIFIC FOR THE SELF ANTIGEN MOUSE CYTOCHROME C

机译：对鸽子细胞色素C的BALB / C小鼠B细胞反应是自体抗原小鼠细胞色素C的特异反应

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摘要

Direct evidence is presented in support of the longstanding but unproven hypothesis that B lymphocytes specific for self antigens (Ags) can be used in the immune response to foreign Ags. We show that the B cells in BALB/c mice responding early to pigeon cytochrome c (CYT) produce antibodies that recognize and bind the major antigenic site on mouse CYT with greater affinity than they bind pigeon CYT-i.e., they are heteroclitic for the self Ag. Furthermore, these B cells express the same combination of immunoglobulin variable region (V) genes that are known to be used in B-cell recognition of mouse CYT. Over time, the response to pigeon CYT becomes more specific for the foreign Ag through the recruitment of B cells expressing different combinations of V genes and, possibly, somatic mutation of the mouse CYT-specific B cells from early in the response. Cross-recognition of pigeon CYT by mouse CYT-specific B cells results from the sharing of critical amino acid residues by the two Ags. Although B-cell recognition of the self Ag, mouse CYT, is very specific, which limits the extent to which foreign Ags can cross-activate the autoreactive B cells, it is possible that polyreactive B cells to other self Ags may be used more frequently in response to foreign Ags.
机译：提供直接证据支持长期但未经证实的假说，即针对自身抗原（Ags）的B淋巴细胞可用于对外来Ags的免疫反应。我们显示，BALB / c小鼠中的B细胞对鸽子细胞色素c（CYT）的早期反应产生的抗体识别并结合小鼠CYT上的主要抗原位点的亲和力大于它们结合鸽子CYT-ie的能力，即它们对于自身是异源的银此外，这些B细胞表达免疫球蛋白可变区（V）基因的相同组合，这些基因已知用于小鼠CYT的B细胞识别。随着时间的流逝，通过募集表达V基因不同组合的B细胞以及可能从响应初期开始的小鼠CYT特异性B细胞的体细胞突变，对鸽子CYT的反应对外来Ag更具特异性。小鼠CYT特异性B细胞对CYT的交叉识别是由两个Ag共享关键氨基酸残基引起的。尽管对自身Ag（小鼠CYT）的B细胞识别非常特殊，这限制了外源Ag可以交叉激活自身反应性B细胞的程度，但可能会更频繁地将多反应性B细胞与其他自身Ag结合使用回应外国Ag。

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