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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >STIMULATION OF PROTECTIVE CD8(+) T LYMPHOCYTES BY VACCINATION WITH NONLIVING BACTERIA
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STIMULATION OF PROTECTIVE CD8(+) T LYMPHOCYTES BY VACCINATION WITH NONLIVING BACTERIA

机译：接种有细菌的细菌可刺激保护性CD8（+）T淋巴细胞。

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摘要

Infectious diseases caused by intracellular microbes are responsible for major health problems, and satisfactory control will ultimately depend on efficient vaccination strategies. The general assumption is that activation of protective immune responses against intracellular microbes dominated by CD8(+) T cells are achieved only by live vaccines. In contrast, we here demonstrate stimulation of protective immunity in mice against the intracellular pathogen Listeria monocytogenes by vaccination with heat-killed listeriae. Vaccine-induced immunity comprised cytolytic and interferon gamma-producing CD8(+) T lymphocytes. CD8(+) T cells from vaccinated donor mice transferred protection against listeriosis. Moreover, vaccination with heat-killed listeriae induced protection in CD4(+) T-cell-deficient, H2-A beta gene-disrupted mutant mice. We conclude that antigens from killed listeriae are introduced into the major histocompatibility complex class I pathway and thus are recognized by CD8(+) T cells. The practicability of killed vaccines against human infectious diseases therefore should be reevaluated.
机译：由细胞内微生物引起的传染病是造成重大健康问题的原因，而令人满意的控制最终将取决于有效的疫苗接种策略。一般的假设是，仅通过活疫苗即可实现针对CD8（+）T细胞占主导的细胞内微生物的保护性免疫应答的激活。相比之下，我们在这里证明了通过用热灭活的李斯特菌疫苗接种来刺激小鼠针对细胞内病原体单核细胞增生李斯特菌的保护性免疫。疫苗诱导的免疫包括溶细胞和产生γ干扰素的CD8（+）T淋巴细胞。来自接种疫苗的供体小鼠的CD8（+）T细胞转移了针对李斯特氏菌病的保护。而且，用热杀死的李斯特菌疫苗接种可在CD4（+）T细胞缺陷型H2-A beta基因破坏的突变小鼠中诱导保护作用。我们得出的结论是，来自杀死的李斯特菌的抗原被引入到主要的组织相容性复合体I类途径中，并因此被CD8（+）T细胞识别。因此，应重新评估针对人类传染病的灭活疫苗的实用性。

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