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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase
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DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase

机译：DNA损伤检查点触发自噬以调节后期启动

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摘要

Chromosome double-strand breaks (DSBs) threaten the integrity of the genome. Cells respond to DSBs by activating the DNA damage checkpoint that blocks cells from entering mitosis, allowing more time for the repair of damaged DNA. When DSBs can be repaired, the cell cycle checkpoint is turned off so that cells can resume cell cycle progression (recovery). If DSBs remain unrepaired, G2/M arrest persists but eventually cells adapt, complete mitosis, and divide. In budding yeast (Saccharomyces cerevisiae), it is possible to create DSB damage synchronously in all cells, either by uncapping telomeres, exposing their normally protected ends, or by creating a single defined DSB by inducing the site-specific HO endonucle-ase.
机译：染色体双链断裂（DSB）威胁基因组的完整性。细胞通过激活可阻止细胞进入有丝分裂的DNA损伤检查点来响应DSB，从而为修复受损的DNA提供了更多时间。可以修复DSB时，将关闭细胞周期检查点，以便细胞可以恢复细胞周期进程（恢复）。如果DSB仍未修复，则G2 / M阻滞仍然存在，但最终细胞会适应，完成有丝分裂并分裂。在发芽酵母（酿酒酵母）中，可以通过解开端粒，暴露其正常保护的末端或通过诱导位点特异性HO内切核酸酶产生单个定义的DSB，在所有细胞中同步产生DSB损伤。

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  • 作者

    Farokh Dotiwala; Vinay V. Eapen; Jacob C. Harrison; Ayelet Arbel-Eden; Vikram Ranade; Satoshi Yoshida; James E. Haber;

  • 作者单位

    Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02445,Harvard Medical School, Boston,MA 02115;

    Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02445;

    Samsung Advanced Institute of Technology, Cambridge, MA 02142;

    Hadassah Academic College, Jerusalem 91010, Israel;

    Department of Genetics and Development, Columbia University, New York, NY 10032;

    Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02445;

    Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02445;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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