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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase
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Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase

机译：非受体酪氨酸磷酸酶Shp2通过抑制p38 MAP激酶促进脂肪形成

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摘要

Obesity has reached an epidemic level worldwide, partly due to decreased physical activity and increased intake of palatable high-calorie foods. Accordingly, efforts devoted to understanding and pharmaceutical intervention of obesity are in progress. Identification of leptin, a hormone secreted by adipocytes, represents a breakthrough in understanding the physiology of energy balance and obesity (1). Unfortunately, the therapeutic value of leptin is limited, as most obese subjects exhibit hyperleptinemia and leptin resistance rather than leptin deficiency. Evidence indicates that obesity is a high-risk factor for type 2 diabetes, hypertension, liver disorders, and some types of cancer.
机译：肥胖症在世界范围内已达到流行病的程度，部分原因是体育活动减少和可口的高热量食物摄入增加。因此，致力于肥胖的理解和药物干预的工作正在进行中。瘦素（一种脂肪细胞分泌的激素）的鉴定代表了在理解能量平衡和肥胖症生理学方面的突破（1）。不幸的是，瘦素的治疗价值是有限的，因为大多数肥胖的受试者表现出高瘦素血症和瘦素抵抗性而不是瘦素缺乏症。有证据表明，肥胖是2型糖尿病，高血压，肝病和某些类型癌症的高危因素。

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    Zhao He; Helen H. Zhu; Timothy J. Bauler; Jing Wang; Theodore Ciaraldi; Nazilla Alderson; Shuangwei Li; Marie-Astrid Raquil; Kaihong Ji; Shufen Wang; Jianhua Shao; Robert R. Henry; Philip D. King; Gen-Sheng Feng;

  • 作者单位

    Department of Pathology and Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0864;

    Department of Pathology and Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0864;

    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109-5620;

    Department of Pathology and Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0864;

    Veteran's Administration San Diego Healthcare System and Department of Medicine, University of California at San Diego, La Jolla.CA 92093;

    Department of Pathology and Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0864;

    Department of Pathology and Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0864;

    Department of Pathology and Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0864;

    Department of Pathology and Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0864;

    Department of Pathology and Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0864;

    Veteran's Administration San Diego Healthcare System Department of Pediatrics, University of California at San Diego, La Jolla,CA 92093;

    Veteran's Administration San Diego Healthcare System and Department of Medicine, University of California at San Diego, La Jolla.CA 92093;

    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109-5620;

    Department of Pathology and Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0864;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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