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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Maternal exposure to bisphenol A and genistein has minimal effect on A~(vy)/a offspring coat color but favors birth of agouti over nonagouti mice
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Maternal exposure to bisphenol A and genistein has minimal effect on A~(vy)/a offspring coat color but favors birth of agouti over nonagouti mice

机译：母体暴露于双酚A和染料木黄酮对A〜（vy）/后代的皮毛颜色影响最小，但比无agouti小鼠更有利于agouti的出生

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摘要

Reports that maternal diet influences coat color in mouse offspring carrying the agouti A~(vy) allele have received considerable attention because the range, from pseudoagouti (brown) to yellow, predicts adult health outcomes, especially disposition toward obesity and diabetes, in yellower mice. Bisphenol A (BPA), an endocrine-disrupting compound with estrogenic properties, fed to a/a dams harboring A~(vy)/a conceptuses has been reported to induce a significant shift toward yellower mice, whereas consumption of either genistein (G) alone or in combination with BPA led to greater numbers of healthy, brown offspring. Groups of C57/B6 a/a females, which are nonagouti, were fed either a phytoestrogen-free control diet or one of six experimental diets: diets 1-3 contained BPA (50 mg, 5 mg, and 50 μg BPA/kg food, respectively); diet 4 contained G (250 mg/kg food); diet 5 contained G plus BPA (250 and 50 mg/kg food, respectively); and diet 6 contained 0.1 μg of ethinyl estradiol (EE)/kg food. Mice were bred to A~(vy)/a males over multiple parities. In all, 2,824 pups from 426 litters were born. None of the diets provided any significant differences in relative numbers of brown, yellow, or intermediate coat color A~(vy)/a offspring. However, BPA plus G (P < 0.0001) and EE diets (P = 0.005), but not the four others, decreased the percentage of black (a/a) to A~(vy)/a offspring from the expected Mendelian ratio of 1:1. Data suggest that A~(vy)/a conceptuses, which may possess a so-called "thrifty genotype," are at a competitive advantage over a/a conceptuses in certain uterine environments.%Biomedical Sciences, University of Missouri, Columbia, MO 65211 Bond Life Sciences Center, University of Missouri, Columbia, MO 65211;rnBiomedical Sciences, University of Missouri, Columbia, MO 65211 Bond Life Sciences Center, University of Missouri, Columbia, MO 65211;rnAnimal Sciences, University of Missouri, Columbia, MO 65211;rnCollege of Agriculture, Food and Natural Resources, University of Missouri, Columbia, MO 65211;rnDivision of Reproductive and Perinatal Research, Department of Obstetrics Gynecology and Women's Health, University of Missouri, Columbia, MO 65212;rnBond Life Sciences Center, University of Missouri, Columbia, MO 65211 Animal Sciences, University of Missouri, Columbia, MO 65211,Department of Biochemistry, University of Missouri, Columbia, MO 65211;
机译：报道说，母亲饮食会影响携带刺豚鼠A〜（vy）等位基因的小鼠后代的皮毛颜色，因此受到了广泛的关注，因为该范围从假拟人（棕色）到黄色可预测成年健康的结果，特别是肥胖小鼠的肥胖和糖尿病倾向。 。据报道，双酚A（BPA）是一种具有雌激素特性的破坏内分泌的化合物，喂入含有A〜（vy）/ a概念的a / a水坝会引起向黄小鼠的明显转变，而食用任一染料木黄酮（G）单独或与BPA结合使用可导致更多健康的棕色后代。每天以非植物雌激素对照饮食或六种实验饮食之一喂食成群的C57 / B6 a / a雌性或非实验动物饮食：饮食1-3含BPA（50 mg，5 mg和50μgBPA / kg食品） ， 分别）;饮食4含G（250 mg / kg食物）；饮食5含有G和BPA（分别为250和50 mg / kg食物）；饮食6中每公斤食物含0.1微克乙炔雌二醇（EE）。通过多个胎次将小鼠繁殖给A〜（vy）/ a雄性。总共出生了426窝幼仔中的2,824只。没有一种饮食在棕色，黄色或中间毛色A〜（vy）/ a后代的相对数量上有任何显着差异。但是，BPA加G（P <0.0001）和EE饮食（P = 0.005），而不是其他四种饮食，使黑色（a / a）占A〜（vy）/ a后代的百分比从预期的孟德尔比率降低了。 1：1数据表明，在某些子宫环境中，可能具有所谓的“节俭基因型”的A〜（vy）/ a概念菌比a / a概念菌具有竞争优势。％密苏里州密苏里大学生物医学65211;密苏里大学，密苏里州，邦德生命科学中心65211; rn密苏里大学，密苏里州，密苏里州，生物医学65211，密苏里州大学，密苏里州，密苏里州，65211; rn，密苏里大学，密苏里州大学，动物科学65211； rn密苏里大学，农业，食品和自然资源学院，密苏里州65211； rn密苏里大学妇产科和妇女健康系生殖和围产期研究，密苏里州65212； rn大学的债券生命科学中心密苏里州，密苏里州，密苏里州65211，密苏里大学，密苏里州，密苏里州65211，密苏里大学，生物化学系，密苏里州，密西根州65211；

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  • 作者

    Cheryl S. Rosenfeld; Paizlee T. Sieli; Denise A. Warzak; Mark R. Ellersieck; Kathleen A. Pennington; R. Michael Roberts;

  • 作者单位

    Biomedical Sciences, University of Missouri, Columbia, MO 65211 Bond Life Sciences Center, University of Missouri, Columbia, MO 65211;

    Biomedical Sciences, University of Missouri, Columbia, MO 65211 Bond Life Sciences Center, University of Missouri, Columbia, MO 65211;

    Animal Sciences, University of Missouri, Columbia, MO 65211;

    College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, MO 65211;

    Division of Reproductive and Perinatal Research, Department of Obstetrics Gynecology and Women's Health, University of Missouri, Columbia, MO 65212;

    Bond Life Sciences Center, University of Missouri, Columbia, MO 65211 Animal Sciences, University of Missouri, Columbia, MO 65211,Department of Biochemistry, University of Missouri, Columbia, MO 65211;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    endocrine disruption; pregnancy; viable yellow mouse; epigenetics; metabolic disease;

    机译：内分泌干​​扰怀孕;可行的黄色鼠标;表观遗传学代谢性疾病;

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