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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Activation of NF-κB signalling by fusicoccin-induced dimerization
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Activation of NF-κB signalling by fusicoccin-induced dimerization

机译：融合霉素诱导的二聚化激活NF-κB信号传导

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摘要

Chemical-induced dimerization (CID) is used to facilitate the spatial proximity of proteins using a chemical compound, known as a "dimerizer," which acts as "molecular glue." CID has become an important tool in the field of chemical biology for deciphering the cellular functions of proteins. Here, we introduce a CID system based on the natural product fusi-coccin and show that this molecule can be used to direct proteins to various subcellular localizations, such as the nucleus, the plasma membrane, or the cytoplasm, where it induces physiological events such as the secretion of IL-8, an immunoregulatory protein produced by white blood cells. In addition to basic research applications, this system potentially can enable chemical control in a therapeutical/clinical setting, for example, by directing the release of insulin or human growth hormone.
机译：化学诱导的二聚化（CID）用于通过一种称为“分子胶”的化合物来促进蛋白质的空间邻近性。 CID已成为化学生物学领域破译蛋白质细胞功能的重要工具。在这里，我们介绍了一种基于天然产物fusi-coccin的CID系统，并表明该分子可用于将蛋白质引导至各种亚细胞定位，例如细胞核，质膜或细胞质，从而诱导诸如此类的生理事件。 IL-8是白细胞产生的一种免疫调节蛋白。除基础研究应用外，该系统还可以通过指导胰岛素或人类生长激素的释放，在治疗/临床环境中实现化学控制。

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  • 作者

    Malgorzata Skwarczynska; Manuela Molzan; Christian Ottmann;

  • 作者单位

    Chemical Genomics Centre of the Max Planck Society, 44227 Dortmund, Germany;

    Chemical Genomics Centre of the Max Planck Society, 44227 Dortmund, Germany;

    Chemical Genomics Centre of the Max Planck Society, 44227 Dortmund, Germany,Laboratory of Chemical Biology, Department of Biomedical Engineering, Technical University of Eindhoven, 5612 AZ Eindhoven, The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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