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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti
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Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti

机译：Wolbachia诱导Toll途径依赖活性氧（ROS）的活化来控制埃及伊蚊中的登革热病毒

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摘要

Wolbachia is a genus of bacteria that inhabits a variety of insect hosts. These symbiotic bacteria are transmitted through the female individuals and can spread within insect host populations because of their unique ability to manipulate reproduction (1). When introduced to nonnative mosquito hosts (i.e., a species lacking Wolbachia), the bacteria induce resistance in the mosquitoes to a number of pathogens that cause human disease, including dengue virus (DENV), Plasmodium, and filarial nematodes (2-4). Thus, Wolbachia could be explored as a potential tool in the control of mosquito-borne diseases.
机译：沃尔巴氏菌是一种细菌，栖息于多种昆虫宿主中。这些共生细菌通过雌性个体传播，并因其操纵繁殖的独特能力而在昆虫寄主种群中传播（1）。当被引入非本地蚊子宿主（即缺乏沃尔巴克氏菌的物种）时，细菌会在蚊子中诱导对引起人类疾病的多种病原体的抵抗力，包括登革热病毒（DENV），疟原虫和丝状线虫（2-4）。因此，可以将Wolbachia视为控制蚊媒疾病的潜在工具。

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    Xiaoling Pan; Guoli Zhou; Jiahong Wu; Guowu Bian; Peng Lu; Alexander S. Raikhel; Zhiyong Xi;

  • 作者单位

    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Ml 48824;

    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Ml 48824;

    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Ml 48824,Department of Parasitology, Guiyang Medical College, Guiyang, Guizhou 550004, China;

    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Ml 48824,Sun Yat-sen University - Michigan State University Joint Center of Vector Control for Tropical Diseases, Guangzhou, Guangdong 510080, China;

    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Ml 48824;

    Department of Entomology and "Institute for Integrative Genome Biology, University of California, Riverside, CA 92521,;

    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Ml 48824,Sun Yat-sen University - Michigan State University Joint Center of Vector Control for Tropical Diseases, Guangzhou, Guangdong 510080, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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