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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Evolutionary conservation of the habenular nuclei and their circuitry controlling the dopamine and 5-hydroxytryptophan (5-HT) systems
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Evolutionary conservation of the habenular nuclei and their circuitry controlling the dopamine and 5-hydroxytryptophan (5-HT) systems

机译：ha状核的进化保守性及其控制多巴胺和5-羟色氨酸（5-HT）系统的电路

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摘要

To survive, all animals need to adapt their behavior in response to rewards, fear-inducing stimuli, and other motivating factors. Recent evidence in mammals has suggested that the habenular nuclei, neural areas comprising the medial and lateral habenulae and located in the epithalamus, play a key role in these processes, as well as in major psychiatric diseases such as depression and schizophrenia (1). The neural circuitry containing these nuclei may constitute a fundamental architecture for adaptive behavior because the habenula is present in all classes of vertebrates. To elucidate the conserved habenula circuitry and approach an understanding of its basic function, we investigated the organization of these nuclei in the lamprey, one of the evolutionarily oldest vertebrates. We report here that the detailed circuitry and connectivity of the two habenular nuclei are present in this species. This circuitry therefore appears to have formed part of the evolution's blueprint for the vertebrate brain over 560 million years ago. Using a combination of techniques to determine the molecular expression and connectivity of the habenula, we found that homologs (i.e., equivalent structures that are conserved from a common ancestor) of the medial and lateral habenulae are present in lampreys and that the circuitry that delivers "commands" to other parts of the nervous system is homologous to that of mammals. As in mammals, separate populations of neurons in the homolog of the lateral habenula project directly to the major forebrain neuromodulatory systems (dopamine, serotonin, and histamine) that are known to regulate, among other things, attention, motivation, and arousal. In addition, a separate population of neurons in the lateral habenula homolog can influence these neuromodulatory systems indirectly through projections to a nucleus containing neurons with the inhibitory neurotransmitter GABA, which, in turn, projects to the dopaminergic and serotonergic nuclei.
机译：为了生存，所有动物都需要适应其行为，以应对奖赏，诱发恐惧的刺激和其他激励因素。哺乳动物中的最新证据表明，位于上丘脑的，位于内侧和外侧的哈贝努尔的ha状核，神经区域，在这些过程以及诸如抑郁症和精神分裂症等主要精神疾病中起着关键作用（1）。包含这些核的神经回路可能构成适应行为的基本体系结构，因为在所有类型的脊椎动物中都存在羽管。为了阐明保守的哈贝努尔回路并了解其基本功能，我们研究了七rey鳗（进化最古老的脊椎动物之一）中这些核的组织。我们在这里报告，该物种中存在两个哈贝核的详细电路和连通性。因此，在5.6亿年前，这种电路似乎已经形成了脊椎动物大脑进化蓝图的一部分。通过结合使用多种技术来确定哈贝瘤的分子表达和连通性，我们发现七rey鳗存在于内侧和外侧哈贝瘤的同系物（即，从共同祖先保守的等效结构）。神经系统其他部位的“指令”与哺乳动物的同源。如在哺乳动物中，外侧哈贝努尔同源物中的单独神经元群体直接投射到主要的前脑神经调节系统（多巴胺，5-羟色胺和组胺），已知这些系统调节着注意力，动机和唤醒。此外，外侧汉族同系物中的一个单独的神经元群体可以通过投射到含有抑制性神经递质GABA的神经元核而间接影响这些神经调节系统，而神经递质GABA则投射到多巴胺能和血清素能核。

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    Marcus Stephenson-Jones; Orestis Floras; Brita Robertson; Sten Grillner;

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    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Instituted SE-171 77 Stockholm, Sweden;

    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Instituted SE-171 77 Stockholm, Sweden;

    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Instituted SE-171 77 Stockholm, Sweden;

    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Instituted SE-171 77 Stockholm, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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