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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Forkhead box N4 (Foxn4) activates DII4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors
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Forkhead box N4 (Foxn4) activates DII4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors

机译：前叉箱N4（Foxn4）激活DII4-Notch信号转导，以抑制早期视网膜祖细胞的感光细胞命运

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摘要

The generation of diverse types of neurons is crucial in the development of the CNS. In vertebrates, neurons are usually specified and differentiated from progenitor cells that are "multipotent," that is, capable of producing two or more types of neurons and related cells. It is unknown how each of these fates is selected from the multiple possibilities. Here, we use various methods to investigate how a particular protein [forkhead/ winged helix transcription factor (TF) Foxn4] helps determine these cell fates; we found that it suppresses alternative fates by selectively activating a specific signaling pathway, DU4-Notch. Progenitors of retinal cells must acquire the ability (referred to as competence) to generate the full range of retinal cell types (1, 2), such as ganglion, amacrine, horizontal, cone, and rod cells (Fig. P1A). We have shown previously that the Foxn4 protein is required to establish the competence for two such cell types in the retina: amacrine and horizontal cells (3).
机译：多种类型的神经元的产生对于中枢神经系统的发展至关重要。在脊椎动物中，通常指定神经元并将其与“多能”祖细胞区分开，即能够产生两种或更多种类型的神经元和相关细胞。未知如何从多种可能性中选择这些命运。在这里，我们使用各种方法来研究特定蛋白质[前叉/翅螺旋转录因子（TF）Foxn4]如何帮助确定这些细胞命运。我们发现它通过选择性激活特定的信号通路DU4-Notch来抑制其他命运。视网膜细胞的祖细胞必须具备产生各种类型的视网膜细胞（1、2）的能力（称为能力），例如神经节细胞，无长突细胞，水平细胞，视锥细胞和视杆细胞（图P1A）。先前我们已经证明Foxn4蛋白是建立视网膜中两种这种细胞类型的能力所必需的：无长突细胞和水平细胞（3）。

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    Huijun Luo; Kangxin Jin; Zhenhui Xie; Feng Qiu; Shengguo Li; Min Zou; Li Cai; Katsuto Hozumi; David T. Shima; Mengqing Xiang;

  • 作者单位

    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854;

    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854;

    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854;

    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854;

    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854;

    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854;

    Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854;

    Department of Immunology and Research Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Kanagawa 259-1193, Japan;

    Laboratory for Translational Vision Research, University College London Institute of Ophthalmology, London EC1V 9EL, United Kingdom;

    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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