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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled
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Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled

机译：Wnt /β-catenin信号传导要求Disheveled DEP结构域和C末端与Frizzled中的不连续基序相互作用

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摘要

Wnt proteins control embryonic development and are implicated in tumorigenesis. The complex molecular mechanisms mediating Wnt-induced cell responses are of wide interest, and the underlying protein interactions provide an attractive drug target, particularly in cancer treatment. However, the initiating step by which Wnts steer cellular signaling cascades and, ultimately, drive gene activation remains a major unresolved question. Here, we provide key mechanistic insight into how Wnt forms stable protein signaling complexes at the plasma membrane to induce downstream gene activation.
机译：Wnt蛋白控制胚胎发育，并与肿瘤发生有关。介导Wnt诱导的细胞反应的复杂分子机制引起广泛关注，并且潜在的蛋白质相互作用提供了有吸引力的药物靶标，尤其是在癌症治疗中。但是，Wnts指导细胞信号传导级联并最终驱动基因激活的起始步骤仍然是一个主要未解决的问题。在这里，我们提供了有关Wnt如何在质膜上形成稳定的蛋白质信号复合物以诱导下游基因激活的关键机制的见解。

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    Daniele V. F. Tauriello; Ingrid Jordens; Katharina Kirchner; Jerry W. Slootstra; Tom Kruitwagen; Britta A. M. Bouwman; Maria Noutsou; Stefan G. D. Riidiger; Klaus Schwamborn; Alexandra Schambony; Madelon M. Maurice;

  • 作者单位

    Department of Cell Biology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands,Institute for Research in Biomedicine Barcelona, 08023 Barcelona, Spain;

    Department of Cell Biology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands;

    Developmental Biology Unit, Department of Biology and Developmental Biology, Friedrich-Alexander University Erlangen-Nuremberg, 91058 Erlangen, Germany;

    Pepscan Therapeutics BV, 8243 RC Lelystad, The Netherlands;

    Department of Cell Biology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands;

    Department of Cell Biology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands;

    Department of Cell Biology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands;

    Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, 3584 CH Utrecht, The Netherlands;

    Pepscan Therapeutics BV, 8243 RC Lelystad, The Netherlands;

    Developmental Biology Unit, Department of Biology and Developmental Biology, Friedrich-Alexander University Erlangen-Nuremberg, 91058 Erlangen, Germany;

    Department of Cell Biology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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