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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Distributed representation of chemical features and tunotopic organization of glomeruli in the mouse olfactory bulb
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Distributed representation of chemical features and tunotopic organization of glomeruli in the mouse olfactory bulb

机译：小鼠嗅球中肾小球的化学特征和肾小球组织的分布式表示

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摘要

In the mammalian brain, similar features of the sensory stimuli are often represented in proximity in the sensory areas. However, how chemical features are represented in the olfactory bulb has been controversial. Questions have been raised as to whether specific chemical features of the odor molecules are represented by spatially clustered olfactory glomeruli. Using a sensitive probe, we have analyzed the glomerular response to large numbers of odorants at single glomerulus resolution. Contrary to the general view, we find that the representation of chemical features is spatially distributed in the olfactory bulb with no discernible chemotopy. Moreover, odorevoked pattern of activity does not correlate directly with odor structure in general. Despite the lack of spatial clustering or preference with respect to chemical features, some structurally related odors can be similarly represented by ensembles of spatially distributed glomeruli, providing an explanation of their perceptual similarity. Whereas there is no chemotopic organization, and the glomeruli are tuned to odors from multiple classes, we find that the glomeruli are hierarchically arranged into clusters according to their odortuning similarity. This tunotopic arrangement provides a framework to understand the spatial organization of the glomeruli that conforms to the organizational principle found in other sensory systems.
机译：在哺乳动物的大脑中，感觉刺激的相似特征通常在感觉区域的邻近处表现出来。然而，如何在嗅球中表现化学特征一直是有争议的。已经提出了关于气味分子的特定化学特征是否由空间聚集的嗅觉肾小球代表的问题。使用灵敏的探针，我们已经在单个肾小球分辨率下分析了肾小球对大量气味剂的反应。与一般观点相反，我们发现化学特征的表示在嗅球中是空间分布的，没有可分辨的化学成分。而且，通常，气味诱发的活动模式与气味结构不直接相关。尽管缺少空间上的聚类或相对于化学特征的偏爱，但一些结构上相关的气味仍可以由空间分布的肾小球的集合类似地表示，从而提供了它们的感知相似性的解释。尽管没有化学组织，并且肾小球被调节成来自多种类别的气味，但是我们发现肾小球根据它们的气味调节相似性被分层排列成簇。这种tu位排列提供了一个框架，以了解与其他感觉系统中发现的组织原理相符的肾小球的空间组织。

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  • 作者

    Limei Ma; Qiang Qiu; Stephen Gradwohl; Aaron Scott; Elden Q. Yu; Richard Alexander; Winfried Wiegraebe; C. Ron Yu;

  • 作者单位

    Stowers Institute for Medical Research, Kansas City, MO 64110;

    Stowers Institute for Medical Research, Kansas City, MO 64110;

    Stowers Institute for Medical Research, Kansas City, MO 64110, Washington University School of Medicine, St. Louis, MO 63110;

    Stowers Institute for Medical Research, Kansas City, MO 64110, University of Missouri School of Medicine, Columbia, MO 65212;

    Stowers Institute for Medical Research, Kansas City, MO 64110;

    Stowers Institute for Medical Research, Kansas City, MO 64110;

    Stowers Institute for Medical Research, Kansas City, MO 64110;

    Stowers Institute for Medical Research, Kansas City, MO 64110 Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    GCaMP2; calcium imaging; topographic map;

    机译：GCaMP2;钙成像地形图;

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