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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Snapshot of virus evolution in hypersaline environments from the characterization of a membrane-containing Salisaeta icosahedral phage 1
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Snapshot of virus evolution in hypersaline environments from the characterization of a membrane-containing Salisaeta icosahedral phage 1

机译：从高盐环境中包含膜的Salisaeta二十面体噬菌体1的特征描述病毒进化的快照

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摘要

The multitude of archaea and bacteria inhabiting extreme environments has only become evident during the last decades. As viruses apply a significant evolutionary force to their hosts, there is an inherent value in learning about viruses infecting these extremophiles. In this study, we have focused on one such unique virus-host pair isolated from a hypersaline environment: an icosahedral, membrane-containing double-stranded DNA virus-Salisaeta icosahedral phage 1 (SSIP-1) and its halophilic host bacterium Salisaeta sp. SP9-1 closely related to Salisaeta longa. The architectural principles, virion composition, and the proposed functions associated with some of the ORFs of the virus are surprisingly similar to those found in viruses belonging to the PRD1-adenovirus lineage. The virion structure, determined by electron cryomicroscopy, reveals that the bulk of the outer protein capsid is composed of upright standing pseudohexameric capsomers organized on a 7= 49 icosahedral lattice. Our results give a comprehensive description of a halophilic virus-host system and shed light on the relatedness of viruses based on their virion architecture.
机译：居住在极端环境中的许多古细菌和细菌仅在最近几十年中才变得明显。由于病毒对宿主施加重要的进化力，因此了解感染这些极端微生物的病毒具有内在价值。在这项研究中，我们集中于从高盐环境中分离出的一种此类独特的病毒-宿主对：二十面体，含有膜的双链DNA病毒-Salisaeta二十面体噬菌体1（SSIP-1）及其嗜盐宿主细菌Salisaeta sp。 SP9-1与Salisaeta longa密切相关。与病毒的一些ORF相关的结构原理，病毒体组成和拟议功能与在PRD1腺病毒谱系的病毒中发现的相似。通过电子低温显微镜检查确定的病毒体结构表明，大部分外部蛋白质衣壳是由直立的伪六聚体衣壳组成的，其组织成7 = 49的二十面体晶格。我们的研究结果对嗜盐病毒宿主系统进行了全面描述，并基于病毒体结构阐明了病毒的相关性。

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  • 作者

    Antti P. Aalto; David Bitter; Janne J. Ravantti; Dennis H. Bamford; Juha T. Huiskonen; Hanna M. Oksanen;

  • 作者单位

    Institute of Biotechnology and Department of Biosciences, Biocenter 2, University of Helsinki, FI-00014, Helsinki, Finland;

    Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford 0X3 7BN, United Kingdom;

    Institute of Biotechnology and Department of Biosciences, Biocenter 2, University of Helsinki, FI-00014, Helsinki, Finland;

    Institute of Biotechnology and Department of Biosciences, Biocenter 2, University of Helsinki, FI-00014, Helsinki, Finland;

    Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford 0X3 7BN, United Kingdom;

    Institute of Biotechnology and Department of Biosciences, Biocenter 2, University of Helsinki, FI-00014, Helsinki, Finland;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    virus structure; PRD1-like viruses; ORFan;

    机译：病毒结构;PRD1样病毒;范范;

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