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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Anxiety in liver X receptor p knockout female mice with loss of glutamic acid decarboxylase in ventromedial prefrontal cortex
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Anxiety in liver X receptor p knockout female mice with loss of glutamic acid decarboxylase in ventromedial prefrontal cortex

机译：腹侧前额叶皮层中谷氨酸脱羧酶丢失的肝X受体p基因敲除雌性小鼠的焦虑

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摘要

Anxiety disorders are the most prevalent mental disorders in adolescents in the United States. Female adolescents are more likely than males to be affected with anxiety disorders, but less likely to have behavioral and substance abuse disorders. The prefrontal cortex (PFC), amygdala, and dorsal raphe are known to be involved in anxiety disorders. Inhibitory input from the PFC to the amygdala controls fear and anxiety typically originating in the amygdala, and disruption of the inhibitory input from the PFC leads to anxiety, fear, and personality changes. Recent studies have implicated liver X receptor p (LXRp) in key neurodevelopmen-tal processes and neurodegenerative diseases. In the present study, we used elevated plus-maze, startle and prepulse inhibition, open field, and novel object recognition tests to evaluate behavior in female LXRβ KO (LXRβ~(-/-)) mice. We found that the female LXRβ~(-/-) mice were anxious with impaired behavioral responses but normal locomotion and memory. Immunohisto-chemistry analysis revealed decreased expression of the enzyme responsible for GABA synthesis, glutamic acid decarboxylase (65+67), in the ventromedial PFC. Expression of tryptophan hy-droxylase 2 in the dorsal raphe was normal. We conclude that the anxiogenic phenotype in female LXRβ~(-/-) mice is caused by reduced GABAergic input from the ventromedial PFC to the amygdala.
机译：焦虑症是美国青少年中最普遍的精神疾病。女性青少年比男性更有可能患上焦虑症，但较少出现行为和药物滥用疾病。已知前额叶皮层（PFC），杏仁核和背ra肌都参与了焦虑症。从PFC到杏仁核的抑制性输入控制了通常起源于杏仁核的恐惧和焦虑，而从PFC抑制性输入的破坏导致焦虑，恐惧和性格改变。最近的研究表明肝脏X受体p（LXRp）与关键的神经发育过程和神经退行性疾病有关。在本研究中，我们使用升高的迷宫，惊吓和预脉冲抑制，开阔场以及新颖的物体识别测试来评估雌性LXRβKO（LXRβ〜（-/-））小鼠的行为。我们发现，雌性LXRβ〜（-/-）小鼠的行为反应受损但运动和记忆正常，因此焦虑。免疫组织化学分析显示，腹侧PFC中负责GABA合成的酶谷氨酸脱羧酶（65 + 67）的表达降低。色氨酸羟化酶2在背缝中的表达正常。我们得出的结论是，雌性LXRβ〜（-/-）小鼠的焦虑表型是由从腹侧PFC到杏仁核的GABA能输入减少所引起的。

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  • 作者

    Xin-jie Tan; Yu-bing Dai; Wan-fu Wu; Margaret Warner; Jan-Ake Gustafsson;

  • 作者单位

    Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204;

    Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204;

    Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204;

    Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204;

    Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204,Center for Biosciences, Department of Biosciences and Nutrition, Novum 141 86, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    psychiatric diseases; inhibitory interneuron; neurotransmitters;

    机译：精神疾病抑制性中间神经元神经递质;

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