Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition

Aleksandra Bielen; Gary Box; Lara Perryman; Lynn Bjerke; Sergey Popov; Yann Jamin; Alexa Jury; Melanie Valenti; Alexis de Haven Brandon; Vanessa Martins; Vincent Romanet; Sebastien Jeay; Florence I. Raynaud; Francesco Hofmann; Simon P. Robinson; Suzanne A. Eccles; Chris Jones

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Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition

机译：Wilms肿瘤细胞对可通过特异性受体抑制靶向的原位异种移植模型中胰岛素样生长因子1信号传导的依赖性

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Wilms tumor is an embryonal renal tumor that accounts for nearly 6% of all pediatric cancers and more than 90% of kidney tumors in children. Although survival is good for the majority of patients, for children with anaplastic or relapsed disease, the clinical outcome remains poor. The insulin-like growth factor 2 (IGF2) may be produced in large amounts in these tumors as a result of loss of heterozy-gosity or loss of imprinting (1,2), genetic and epigenetic mechanisms that result in increased expression of the ligand as a result of preferential targeting of the active allele at this locus.

机译：Wilms肿瘤是一种胚胎性肾脏肿瘤，占所有儿童癌症的近6％，而儿童肾脏肿瘤则占90％以上。尽管对于大多数患者而言，生存期是好的，对于患有间变性或复发性疾病的儿童，其临床结局仍然很差。胰岛素样生长因子2（IGF2）可能由于杂合性缺失或印迹缺失（1,2），遗传和表观遗传机制导致配体表达增加而在这些肿瘤中大量产生。由于活性等位基因优先靶向此基因座。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第20期|p.7604-7605|共2页
作者
Aleksandra Bielen; Gary Box; Lara Perryman; Lynn Bjerke; Sergey Popov; Yann Jamin; Alexa Jury; Melanie Valenti; Alexis de Haven Brandon; Vanessa Martins; Vincent Romanet; Sebastien Jeay; Florence I. Raynaud; Francesco Hofmann; Simon P. Robinson; Suzanne A. Eccles; Chris Jones;
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作者单位

Department of Pediatric Oncology and Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;

Cancer Research United Kingdom Cancer Therapeutics Unit, Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;

Department of Pediatric Oncology and Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;

Department of Pediatric Oncology and Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;

Department of Pediatric Oncology and Institute of Cancer Research, Sutton SM2 5NG, United Kingdom, Department of Pediatric Oncology, Royal Marsden Hospital, Sutton SM2 5PT, United Kingdom;

Cancer Research United Kingdom and Engineering and Physical Sciences Research Council Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Sutton SM2 5NG, United Kingdom;

Department of Pediatric Oncology and Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;

Cancer Research United Kingdom Cancer Therapeutics Unit, Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;

Cancer Research United Kingdom Cancer Therapeutics Unit, Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;

Cancer Research United Kingdom Cancer Therapeutics Unit, Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;

Novartis Pharma, CH-4002 Basel, Switzerland;

Novartis Pharma, CH-4002 Basel, Switzerland;

Cancer Research United Kingdom Cancer Therapeutics Unit, Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;

Novartis Pharma, CH-4002 Basel, Switzerland;

Cancer Research United Kingdom and Engineering and Physical Sciences Research Council Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, Sutton SM2 5NG, United Kingdom;

Cancer Research United Kingdom Cancer Therapeutics Unit, Institute of Cancer Research, Sutton SM2 5NG, United Kingdom;

Department of Pediatric Oncology and Institute of Cancer Research, Sutton SM2 5NG, United Kingdom, Department of Pediatric Oncology, Royal Marsden Hospital, Sutton SM2 5PT, United Kingdom;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. [J] . Desbois Mouthon C, Baron A, Blivet Van Eggelpoel MJ Clinical cancer research: an official journal of the American Association for Cancer Research . 2009,第17期

机译：胰岛素样生长因子-1受体抑制通过表皮生长因子受体/ HER3 / AKT信号传导途径诱导耐药机制：在肝细胞癌中共同靶向胰岛素样生长因子-1受体和表皮生长因子受体的合理依据。
2. Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression. [J] . H Werner, Z Shen-Orr, F J Rauscher, Molecular and Cellular Biology . 1995,第7期

机译：Wilms的肿瘤抑制因子WT1抑制细胞增殖与胰岛素样生长因子I受体基因表达的抑制有关。
3. Effects of epidermal growth factor receptor and insulin-like growth factor 1 receptor inhibition on proliferation and intracellular signaling in cutaneous SCCHN: Potential for dual inhibition as a therapeutic modality [J] . Head and neck: Journal for the sciences and specialities of the head and neck . 2013,第1期

机译：表皮生长因子受体和胰岛素样生长因子1受体抑制对皮肤SCCHN增殖和细胞内信号传导的影响：双重抑制作为治疗手段的潜力
4. Potential Role of Glyceollin as Anti-Metastatic Agent through Transforming Growth Factor-β Receptors Inhibition Signaling Pathways: A Computational Study [C] . Feri Eko Hermanto, Muhaimin Rifai, Widodo International Conference on Biosciences and Medical Engineering . 2019

机译：Glyceollin作为抗转移剂通过转化生长因子-β受体抑制信号通路的潜在作用：计算研究
5. Rule-Based Modeling Project of Insulin-Like Growth Factor and Mechanistic Target of Rapamycin Signaling Network with Site-Specific Interactions. [D] . McIntosh, Lorin Marie. 2017

机译：具有特定部位相互作用的雷帕霉素信号传导网络的胰岛素样生长因子和机制靶标的基于规则的建模项目。
6. PNAS Plus: Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition [O] . Aleksandra Bielen, Gary Box, Lara Perryman, 2012

机译：PNAS Plus：在通过特异性受体抑制作用靶向的原位异种移植模型中Wilms肿瘤细胞对胰岛素样生长因子1信号传导的依赖性
7. Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition [O] . A. Bielen, G. Box, L. Perryman, 2012

机译：Wilms肿瘤细胞对通过特异性受体抑制的原位异种移植模型中胰岛素样生长因子1的信号传导的依赖性

Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition

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