...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP_3 receptors
【24h】

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP_3 receptors

机译：蓖麻油通过蓖麻油酸激活前列腺素EP_3受体诱导松弛和子宫收缩

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Castor oil is one of the oldest drugs. When given orally, it has a laxative effect and induces labor in pregnant females. The effects of castor oil are mediated by ricinoleic acid, a hydroxylated fatty acid released from castor oil by intestinal lipases. Despite the wide-spread use of castor oil in conventional and folk medicine, the molecular mechanism by which ricinoleic acid acts remains unknown. Here we show that the EP_3 prostanoid receptor is specifically activated by ricinoleic acid and that it mediates the pharmacological effects of castor oil. In mice lacking EP_3 receptors, the laxative effect and the uterus contraction induced via ricinoleic acid are absent. Although a conditional deletion of the EP_3 receptor gene in intestinal epithelial cells did not affect castor oil-induced diarrhea, mice lacking EP_3 receptors only in smooth-muscle cells were unresponsive to this drug. Thus, the castor oil metabolite ricinoleic acid activates intestinal and uterine smooth-muscle cells via EP_3 prostanoid receptors. These findings identify the cellular and molecular mechanism underlying the pharmacological effects of castor oil and indicate a role of the EP_3 receptor as a target to induce laxative effects.
机译：蓖麻油是最古老的药物之一。口服时，它具有缓泻作用，并在孕妇中引产。蓖麻油的作用是由蓖麻油酸介导的，蓖麻油酸是通过肠道脂肪酶从蓖麻油中释放出来的羟基化脂肪酸。尽管蓖麻油在常规和民间医学中得到了广泛使用，但蓖麻油酸起作用的分子机理仍然未知。在这里，我们显示EP_3前列腺素受体被蓖麻油酸特异性激活，并且它介导了蓖麻油的药理作用。在缺乏EP_3受体的小鼠中，缺乏通过蓖麻油酸引起的通便作用和子宫收缩。尽管在肠上皮细胞中有条件地删除EP_3受体基因不会影响蓖麻油诱导的腹泻，但仅在平滑肌细胞中缺乏EP_3受体的小鼠对此药无反应。因此，蓖麻油代谢产物蓖麻油酸通过EP_3类前列腺素受体激活肠和子宫平滑肌细胞。这些发现确定了蓖麻油的药理作用基础的细胞和分子机制，并表明EP_3受体作为诱导通便作用的靶标的作用。

著录项

  • 来源
  • 作者

    Sorin Tunaru; Till F. Althoff; Rolf M. Nuesing; Martin Diener; Stefan Offermanns;

  • 作者单位

    Department of Pharmacology, Max-Planck-lnstitute for Heart and Lung Research, 61231 Bad Nauheim, Germany;

    Department of Pharmacology, Max-Planck-lnstitute for Heart and Lung Research, 61231 Bad Nauheim, Germany;

    Institute for Clinical Pharmacology, J. W. Goethe University Frankfurt, 60590 Frankfurt, Germany;

    Institute for Veterinary Physiology, Justus Liebig University, 35392 Giessen, Germany;

    Department of Pharmacology, Max-Planck-lnstitute for Heart and Lung Research, 61231 Bad Nauheim, Germany Medical Faculty, J. W. Goethe University Frankfurt, 60590 Frankfurt, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    G-protein coupled receptor; peristalsis; Ricinus communis; PGE_2;

    机译：G蛋白偶联受体;蠕虫树脂共产主义者;Piji2;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号