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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length
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MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length

机译：MHC II类在树突状细胞和B细胞中的分布取决于泛素链长

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摘要

Dendritic cells (DCs) and B cells present antigen-derived peptides bound to MHC class II (MHC II) molecules for recognition by CD4-positive T lymphocytes. DCs control the intracellular traffic of peptide-MHC II complexes by regulating the ubiquitination of MHC II. In resting or "immature" DCs, ubiquitinated MHC II molecules are targeted to lysosomes, but upon pathogen-induced "maturation," ubiquitination is down-regulated and MHC II can accumulate on the plasma membrane of mature DCs. Although B cells constitu-tively ubiquitinate their MHC II, it unexpectedly remains at the surface. We find that DCs and B cells differ in MHC ll-conjugated ubiquitin (Ub) chain length: four to six Ub in immature DCs vs. two to three in B cells. In both cell types, experimentally increasing Ub chain length led to efficient lysosomal transport of MHC II, whereas MHC II with fewer than two Ubs did not reach lysosomes. Thus, Ub chain length plays a crucial role in regulating the intracellular fate and function of MHC II in DCs and B cells.
机译：树突状细胞（DC）和B细胞呈现与II类MHC（MHC II）分子结合的抗原衍生肽，以被CD4阳性T淋巴细胞识别。 DC通过调节MHC II的泛素化作用来控制肽-MHC II复合物的细胞内运输。在静止或“未成熟”的DC中，泛素化的MHC II分子靶向溶酶体，但是在病原体诱导的“成熟”时，泛素化被下调，MHC II可以积聚在成熟DC的质膜上。尽管B细胞组成性地遍在其MHC II，但它出乎意料地保留在表面。我们发现DC和B细胞在MHC ll偶联的泛素（Ub）链长方面有所不同：未成熟的DC中有4到6个Ub，而B细胞中有2到3个。在这两种细胞类型中，实验上增加的Ub链长导致MHC II的有效溶酶体转运，而少于两个Ub的MHC II没有到达溶酶体。因此，Ub链长度在调节DC和B细胞中MHC II的细胞内命运和功能中起着至关重要的作用。

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    Jessica K. Ma; Mia Y. Platt; Jeffrey Eastham-Anderson; Jeoung-Sook Shin; Ira Mellman;

  • 作者单位

    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520,Genentech, South San Francisco, CA 94080;

    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520,Genentech, South San Francisco, CA 94080;

    Genentech, South San Francisco, CA 94080;

    Department of Microbiology and Immunology, Sandier Asthma Basic Research Center, University of California, San Francisco, CA 94143;

    Genentech, South San Francisco, CA 94080;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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