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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Aurora B kinase phosphorylates and instigates degradation of p53
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Aurora B kinase phosphorylates and instigates degradation of p53

机译:Aurora B激酶磷酸化并促使p53降解

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摘要

Aurora B, a protein kinase, plays a key role in mitosis by maintaining correct chromosome segregation and progression of cells through mitosis. Cancer cells frequently express Aurora B at unusually high levels, leading to dysregulated mitosis and therefore, causing unequal chromosome segregation, which may confer a growth advantage. The tumor suppressor protein p53 guards the genome by delaying or arresting the cell cycle at specific checkpoints (Gl/S) when DNA is damaged and prevents damaged cells from entering mitosis (G2/ M checkpoint).
机译:蛋白激酶Aurora B通过维持正确的染色体分离和通过有丝分裂的细胞进程,在有丝分裂中起关键作用。癌细胞经常以极高的水平表达Aurora B,从而导致有丝分裂失调,从而导致不平等的染色体分离,这可能会带来生长优势。肿瘤抑制蛋白p53通过在DNA受损时延迟或阻止特定检查点(G1 / S)的细胞周期来保护基因组,并防止受损细胞进入有丝分裂(G2 / M检查点)。

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    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Genes and Development,University of Texas, Houston, TX 77330,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Cancer Biology, University of Texas, Houston, TX 77330;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Cancer Biology, University of Texas, Houston, TX 77330;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Cancer Biology, University of Texas, Houston, TX 77330;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Genes and Development,University of Texas, Houston, TX 77330,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Department of Genetics, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Cancer Biology, University of Texas, Houston, TX 77330;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Cancer Biology, University of Texas, Houston, TX 77330;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Cancer Biology, University of Texas, Houston, TX 77330;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Genes and Development,University of Texas, Houston, TX 77330,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,Department ofEmergency Medicine, The M. D. Anderson Cancer Center, University of Texas, Houston,TX 77030,Department of Endocrine Neoplasia and Hormonal Disorders, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030;

    Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Genes and Development,University of Texas, Houston, TX 77330,Department of Molecular and Cellular Oncology, The M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030,The M. D. Anderson Cancer Center, Program in Cancer Biology, University of Texas, Houston, TX 77330;

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