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The instability of stabilization

机译:稳定的不稳定

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摘要

Actin filaments and microtubules control the shape of cells and organize their contents. The proteins that form these cyto-skeletal polymers were identified and isolated decades ago-actin in 1942 (1) and tubulin in 1968 (2)-but we still argue about some of their basic properties. New work from Niedermayer et al. (3), however, puts us on the right track, or more properly back on the right track, to understanding how actin filaments fall apart. After years of study, how is it still possible for otherwise reasonable people to disagree about how actin filaments and microtubules assemble and disassemble? The shortest answer I can think of has two parts: (i) the details matter, and (ii) the experiments are hard.
机译:肌动蛋白丝和微管控制细胞的形状并组织其内容物。数十年前,鉴定并分离了形成这些细胞骨架聚合物的蛋白质-肌动蛋白1942(1)和微管蛋白1968(2)-但我们仍在争论它们的一些基本特性。 Niedermayer等人的新作品。 (3)然而,它使我们处于正确的轨道上,或更恰当地回到正确的轨道上,以了解肌动蛋白丝如何分裂。经过多年的研究,对于其他一些有理智的人,对于肌动蛋白丝和微管是如何组装和拆卸的,还有何不同意见呢?我能想到的最短答案有两个部分:(i)细节很重要,(ii)实验很难。

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