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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Selective requirement for Mediator MED23 in Ras-active lung cancer
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Selective requirement for Mediator MED23 in Ras-active lung cancer

机译：ras-活动性肺癌对介质MED23的选择性需求

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摘要

Lung cancer is the leading cause of cancer-related mortality worldwide and arises from the accumulation of multiple oncogenic lesions. A point mutation in the Ras gene family member, the K-Ras gene, and constitutive activation of the Ras-MAPK signaling pathway are involved in certain lung cancers (1). Efforts to develop Ras-directed therapies are challenged by the difficulty in selectively targeting the activated Ras GTPase (2). Here, we screened a panel of lung cancer cells with and without Ras mutations and demonstrated that MED23, a component of the Mediator complex, and its interacting transcription factor, ELK1, are critical for Ras-driven oncogenesis and may provide potential targets for "undruggable" Ras-driven lung cancer.
机译：肺癌是全球范围内与癌症相关的死亡率的主要原因，并且是由多种致癌病变的积累引起的。 Ras基因家族成员中的点突变，K-Ras基因和Ras-MAPK信号传导途径的组成性激活与某些肺癌有关（1）。选择性靶向激活的Ras GTPase的困难挑战了开发Ras定向疗法的努力（2）。在这里，我们筛选了一组具有和不具有Ras突变的肺癌细胞，并证明MED23（介体复合物的组成部分）及其相互作用的转录因子ELK1对Ras驱动的肿瘤发生至关重要，并可能为“不可药物治疗”拉斯驱动的肺癌。

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    Xu Yang; Meng Zhao; Min Xia; Yuting Liu; Jun Yan; Hongbin Ji; Gang Wang;

  • 作者单位

    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology Chinese Academy of Sciences, Shanghai 200031, China;

    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology Chinese Academy of Sciences, Shanghai 200031, China;

    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology Chinese Academy of Sciences, Shanghai 200031, China;

    Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Institute Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

    Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Institute Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology Chinese Academy of Sciences, Shanghai 200031, China;

    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology Chinese Academy of Sciences, Shanghai 200031, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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