Migraine, a potentially debilitating neurologic condition that, by some estimates, affects up to one-fifth of the general population, is often marked by a wave of electrical activity across the brain's cortex. This wave, called cortical spreading depression, or CSD, is thought to be involved in the pathogenesis of a form of migraine designated by the International Headache Society as "migraine with aura," referring to a constellation of neurologic symptoms that precedes or accompanies an attack. While CSD has been tied to malfunctioning ion channels in neuronal membranes, Alessandro Tozzi et al.
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