Autophagy against tuberculosis

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Autophagy against tuberculosis

机译：自噬抗结核

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Autophagy, a cell biological pathway tied to immune responses, affects cellular processes related to aging, cancer, and neurodegeneration. Previous studies have shown that autophagy acts as a cell-autonomous defense against Mycobacterium tuberculosis, the bacterial pathogen responsible for tuberculosis. But this protective action has not been demonstrated in vivo. Combining a tuberculosis mouse model and a line of transgenic mice with autophagy-deficient macro- phages, Eliseo Castillo et al. (pp. 18645-18646) show that autophagy provides both antibacterial and anti- inflammatory protection against tuberculosis.

机译：自噬是一种与免疫反应相关的细胞生物学途径，它会影响与衰老，癌症和神经变性有关的细胞过程。以前的研究表明，自噬是针对结核分枝杆菌的细胞自主防御，结核分枝杆菌是引起结核病的细菌病原体。但是这种保护作用尚未在体内得到证实。 Eliseo Castillo等人将结核病小鼠模型和一系列具有自噬缺陷型巨噬细胞的转基因小鼠相结合。（pp。18645-18646）显示自噬同时提供了抗结核和抗炎的抗结核保护作用。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第46期|18628-18628|共1页
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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专利

1. Selective autophagy gets more selective: Uncoupling of autophagy flux and xenophagy flux in Mycobacterium tuberculosis-infected macrophages [J] . Chandra Pallavi, Kumar Dhiraj Autophagy . 2016,第3期

机译：选择性自噬变得更具选择性：分枝杆菌血栓分枝杆菌感染巨噬细胞的自噬助焊剂和疾病的疾病
2. Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1 autophagy-promoting cytokine (IFN-gamma) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen. [J] . Ghadimi D, de Vrese M, Heller KJ, International immunopharmacology . 2010,第6期

机译：乳酸菌通过响应结核分枝杆菌抗原增加Th1自噬促进细胞因子（IFN-γ）和一氧化氮（NO）的水平并降低Th2自噬抑制细胞因子（IL-4和IL-13）来增强单核吞噬细胞的自噬能力。。
3. Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy. [J] . Deretic V, Delgado M, Vergne I, Current topics in microbiology and immunology . 2009,第Null期

机译：自噬对结核分枝杆菌的免疫：解剖自噬免疫作用的模型系统。
4. Assessing structural features of tuberculosis using Mueller matrix derived parameters: a quantitative method to distinguish between Crohn's disease and gastrointestinal luminal tuberculosis [C] . Binguo Chen, Honghui He, Hongyi Zhu, Conference on Optics in health care and biomedical optics . 2020

机译：使用穆勒基质衍生参数评估结核病的结构特征：区分克罗恩病和胃肠腔结核的定量方法
5. Mechanisms Promoting Autophagy in Innate Immunity to Mycobacterium tuberculosis [D] . Sakowski, Erik 2015

机译：促进结核分枝杆菌先天免疫自噬的机制
6. Selective autophagy gets more selective: Uncoupling of autophagy flux and xenophagy flux in Mycobacterium tuberculosis-infected macrophages [O] . Pallavi Chandra, Dhiraj Kumar 2016

机译：选择性自噬变得更具选择性：结核分枝杆菌感染的巨噬细胞中自噬通量和异种通量的解偶联
7. Autophagy adaptor protein p62/SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells. [O] . Shintaro Seto, Kunio Tsujimura, Toshinobu Horii, 2013

机译：自噬衔接蛋白p62 / sQsTm1和自噬相关基因atg5介导自噬体形成以响应树突细胞中的结核分枝杆菌感染。

Autophagy against tuberculosis

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