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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Role of prefrontal cortex and the midbrain dopamine system in working memory updating
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Role of prefrontal cortex and the midbrain dopamine system in working memory updating

机译：前额叶皮层和中脑多巴胺系统在工作记忆更新中的作用

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摘要

Humans are adept at switching between goal-directed behaviors quickly and effectively. The prefrontal cortex (PFC) is thought to play a critical role by encoding, updating, and maintaining internal representations of task context in working memory. It has also been hypothesized that the encoding of context representations in PFC is regulated by phasic dopamine gating signals. Here we use multimodal methods to test these hypotheses. First we used functional MRI (fMRI) to identify regions of PFC associated with the representation of context in a working memory task. Next we used single-pulse transcranial magnetic stimulation (TMS), guided spatially by our fMRI findings and temporally by previous event-related EEG recordings, to disrupt context encoding while participants performed the same working memory task. We found that TMS pulses to the right dorsolateral PFC (DLPFC) immediately after context presentation, and well in advance of the response, adversely impacted context-dependent relative to context-independent responses. This finding causally implicates right DLPFC function in context encoding. Finally, using the same paradigm, we conducted high-resolution fMRI measurements in brainstem do-paminergic nuclei (ventral tegmental area and substantia nigra) and found phasic responses after presentation of context stimuli relative to other stimuli, consistent with the timing of a gating signal that regulates the encoding of representations in PFC. Furthermore, these responses were positively correlated with behavior, as well as with responses in the same region of right DLPFC targeted in the TMS experiment, lending support to the hypothesis that dopamine phasic signals regulate encoding, and thereby the updating, of context representations in PFC.
机译：人类善于快速有效地在目标导向的行为之间进行切换。前额叶皮层（PFC）被认为在工作记忆中通过编码，更新和维护任务上下文的内部表示而发挥关键作用。还假设PFC中上下文表示的编码受相位多巴胺门控信号的调节。在这里，我们使用多峰方法来检验这些假设。首先，我们使用功能性MRI（fMRI）来识别与工作记忆任务中的情境表示相关的PFC区域。接下来，我们使用单脉冲经颅磁刺激（TMS），在空间上以我们的功能磁共振成像结果为指导，并在时间上以先前的事件相关性脑电图记录为指导，在参与者执行相同的工作记忆任务时中断上下文编码。我们发现，在情境呈现后，并且在响应之前，TMS会立即向右背外侧PFC（DLPFC）发出脉冲，相对于与情境无关的响应，会对依情关系产生不利影响。这一发现在上下文编码中暗示了正确的DLPFC功能。最后，使用相同的范例，我们在脑干多巴胺能核（腹侧被盖区和黑质）中进行了高分辨率fMRI测量，并发现与其他刺激相关的背景刺激相对于门控信号的时序呈相位响应规范PFC中表示的编码。此外，这些反应与行为以及在TMS实验中针对的右侧DLPFC的同一区域中的反应均呈正相关，这为多巴胺相位信号调节编码并由此更新PFC中上下文表示的假设提供了支持。 。

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    Kimberlee DArdenne; Neir Eshel; Joseph Luka; Agatha Lenartowicz; Leigh E. Nystrom; Jonathan D. Cohen;

  • 作者单位

    Department of Chemistry Princeton University,Princeton, NJ 08544,Princeton Neuroscience Institute Princeton University,Princeton, NJ 08544,Virginia Tech Carilion Research Institute, Roanoke, VA 24016;

    Princeton Neuroscience Institute Princeton University,Princeton, NJ 08544,Department of Molecular Biology, and Princeton University,Princeton, NJ 08544;

    Princeton Neuroscience Institute Princeton University,Princeton, NJ 08544;

    Princeton Neuroscience Institute Princeton University,Princeton, NJ 08544,Department of Psychology, Princeton University,Princeton, NJ 08544;

    Princeton Neuroscience Institute Princeton University,Princeton, NJ 08544;

    Princeton Neuroscience Institute Princeton University,Princeton, NJ 08544,Department of Psychology, Princeton University,Princeton, NJ 08544;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    cognitive control; context updating; task switching; cognitive neuroscience;

    机译：认知控制上下文更新;任务切换;认知神经科学;

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