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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone
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Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone

机译：连接蛋白45调节小鼠脑室下区转运放大前体细胞的增殖

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摘要

Connexins have been implicated in the regulation of precursor cell migration and proliferation during embryonic development of the mammalian brain. However, their function in postnatal neurogenesis is unclear. Here we demonstrate that connexin (Cx) 45 is expressed in transit-amplifying cells and neuroblasts in the postnatal subventricular zone (SVZ) and modulated the proliferation of SVZ-derived precursor cells in vivo. Thus, overexpression of Cx45 by retroviral injections increased the proliferation of Mash-1-positive transit-amplifying precursor cells in the SVZ. Conversely, conditional deletion of Cx4S in precursor cells decreased proliferation. Finally, we established that Cx45 positively influences cell cycle reentry via ATP signaling that involves intracellular calcium stores and ERK1/2 signaling.
机译：连接蛋白与哺乳动物脑胚胎发育过程中前体细胞迁移和增殖的调节有关。但是，它们在产后神经发生中的功能尚不清楚。在这里，我们证明连接蛋白（Cx）45在产后脑室下带（SVZ​​）的转运扩增细胞和成神经细胞中表达，并调节体内SVZ衍生的前体细胞的增殖。因此，逆转录病毒注射引起的Cx45过表达增加了SVZ中Mash-1阳性转运放大前体细胞的增殖。相反，前体细胞中Cx4S的条件缺失会降低增殖。最后，我们确定Cx45通过涉及细胞内钙存储和ERK1 / 2信号传导的ATP信号传导对细胞周期的再进入产生积极影响。

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    Konstantin Khodosevich; Annalisa Zuccotti; Maria M. Kreuzberg; Corentin Le Magueresse; Marina Frank; Klaus Willecke; Hannah Monyer;

  • 作者单位

    Department of Clinical Neurobiology, University Hospital and German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany;

    Department of Clinical Neurobiology, University Hospital and German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany;

    Department of Clinical Neurobiology, University Hospital and German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany;

    Department of Clinical Neurobiology, University Hospital and German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany;

    Life and Medical Sciences (LIMES) Institute, University of Bonn, Carl-Troll-Strasse 31, 53115 Bonn, Germany;

    Life and Medical Sciences (LIMES) Institute, University of Bonn, Carl-Troll-Strasse 31, 53115 Bonn, Germany;

    Department of Clinical Neurobiology, University Hospital and German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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