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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Wounding mobilizes hair follicle stem cells to form tumors
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Wounding mobilizes hair follicle stem cells to form tumors

机译：伤口动员毛囊干细胞形成肿瘤

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摘要

A wide variety of human cancers are associated with injury. Although stem cells participate in tissue regeneration after wounding, it is unclear whether these cells also contribute to epithelial tumors. Human basal cell carcinomas (BCCs) are associated with misactiva-tion of Hedgehog (Hh) signaling, commonly through acquisition of mutations in Smoothened (Smo). We have found that expression of an activated form of Smo by stem cells of the hair-follicle bulge and secondary hair germ does not induce robust Hh signaling or produce BCCs. However, wounding recruits these cells from the follicle to the wound site, where downstream Hh signal transduction is derepressed, giving rise to superficial BCC-like tumors. These findings demonstrate that BCC-like tumors can originate from follicular stem cells and provide an explanation for the association between wounding and tumorigenesis.
机译：各种各样的人类癌症都与伤害有关。尽管干细胞在受伤后参与组织再生，但尚不清楚这些细胞是否也有助于上皮肿瘤。人类基底细胞癌（BCC）与刺猬（Hh）信号的失活有关，通常是通过获取Smoothened（Smo）中的突变来实现的。我们已经发现，毛囊隆起的干细胞和继发性发芽的Smo活化形式的表达不会诱导强健的Hh信号传导或产生BCC。然而，伤口将这些细胞从卵泡募集到伤口部位，在那里下游的Hh信号转导被抑制，从而引起浅表BCC样肿瘤。这些发现表明，BCC样肿瘤可起源于滤泡干细胞，并为伤口与肿瘤发生之间的关联提供了解释。

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