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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia
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MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia

机译：MicroRNA作为B细胞慢性淋巴细胞白血病的生物标志物和调节剂

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摘要

Early cancer detection and disease stratification or classification are critical to successful treatment. Accessible, reliable, and informative cancer biomarkers can be medically valuable and can provide some relevant insights into cancer biology. Recent studies have suggested improvements in detecting malignancies by the use of specific extracellular microRNAs (miRNAs) in plasma. In chronic lymphocytic leukemia (CLL), an incurable hematologic disorder, sensitive, early, and noninvasive diagnosis and better disease classification would be very useful for more effective therapies. We show here that circulating miRNAs can be sensitive biomarkers for CLL, because certain extracellular miRNAs are present in CLL patient plasma at levels significantly different from healthy controls and from patients affected by other hematologic malignancies. The levels of several of these circulating miRNAs also displayed significant differences between zeta-associ-ated protein 70 (ZAP-70)~+ and ZAP-70~- CLL. We also determined that the level of circulating miR-20a correlates reliably with diagnosis-to-treatment time. Network analysis of our data, suggests a regulatory network associated with BCL2 and ZAP-70 expression in CLL This hypothesis suggests the possibility of using the levels of specific miRNAs in plasma to detect CLL and to determine the ZAP-70 status.
机译：早期癌症检测和疾病分层或分类对于成功治疗至关重要。可访问，可靠且信息丰富的癌症生物标记物可能具有医学上的价值，并可以提供一些有关癌症生物学的见解。最近的研究表明，通过在血浆中使用特定的细胞外microRNA（miRNA），可以更好地检测恶性肿瘤。在慢性淋巴细胞性白血病（CLL）中，无法治愈的血液系统疾病，敏感，早期和无创诊断以及更好的疾病分类对于更有效的治疗将非常有用。我们在这里显示，循环的miRNA可能是CLL的敏感生物标志物，因为CLL患者血浆中存在某些细胞外miRNA，其水平与健康对照和受其他血液系统恶性肿瘤影响的患者明显不同。这些循环的miRNA中的几种的水平也显示了与ζ相关的蛋白70（ZAP-70）〜+和ZAP-70〜-CLL之间的显着差异。我们还确定循环miR-​​20a的水平与诊断到治疗的时间可靠相关。对我们数据的网络分析表明，CLL中存在与BCL2和ZAP-70表达相关的调控网络。这一假设表明，可以利用血浆中特定miRNA的水平检测CLL并确定ZAP-70的状态。

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  • 作者

    Etienne Moussay; Kai Wang; Ji-Hoon Cho; Kris van Moer; Sandrine Pierson; Jerome Paggetti; Petr V. Nazarov; Valerie Palissot; Leroy E. Hood; Guy Berchem; David J. Galas;

  • 作者单位

    Laboratory of Experimental Hemato-Oncology, Centre de Recherche Public (CRP)-Sante, L-1526 Luxembourg;

    lnstitute for Systems Biology, Seattle, WA 98103;

    lnstitute for Systems Biology, Seattle, WA 98103;

    Laboratory of Experimental Hemato-Oncology, Centre de Recherche Public (CRP)-Sante, L-1526 Luxembourg;

    Laboratory of Experimental Hemato-Oncology, Centre de Recherche Public (CRP)-Sante, L-1526 Luxembourg;

    Laboratory of Experimental Hemato-Oncology, Centre de Recherche Public (CRP)-Sante, L-1526 Luxembourg;

    Microarray Center, CRP-Sante, L-1526 Luxembourg;

    Laboratory of Experimental Hemato-Oncology, Centre de Recherche Public (CRP)-Sante, L-1526 Luxembourg;

    lnstitute for Systems Biology, Seattle, WA 98103,Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-1511 Luxembourg;

    lnstitute for Systems Biology, Seattle, WA 98103,Department of Hematology, Centre Hospitalier du Luxembourg, L-1210 Luxembourg;

    lnstitute for Systems Biology, Seattle, WA 98103,Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-1511 Luxembourg;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    hairy cell leukemia; multiple myeloma; gene network; nr6a1;

    机译：毛细胞白血病;多发性骨髓瘤;基因网络;nr6a1;

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