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Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti

机译:每日温度波动对埃及伊蚊传播登革热病毒的影响

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摘要

Most studies on the ability of insect populations to transmit pathogens consider only constant temperatures and do not account for realistic daily temperature fluctuations that can impact vector-pathogen interactions. Here, we show that diurnal temperature range (DTR) affects two important parameters underlying dengue virus (DENV) transmission by Aedes aegypti. In two independent experiments using different DENV serotypes, mosquitoes were less susceptible to virus infection and died faster under larger DTR around the same mean temperature. Large DTR (20 ℃) decreased the probability of midgut infection, but not duration of the virus extrinsic incubation period (EIP), compared with moderate DTR (10 ℃) or constant temperature. A thermodynamic model predicted that at mean temperatures <18 ℃ DENV transmission increases as DTR increases, whereas at mean temperatures >18℃, larger DTR reduces DENV transmission. The negative impact of DTR on Ae. aegypti survival indicates that large temperature fluctuations will reduce the probability of vector survival through EIP and expectation of infectious life. Seasonal variation in the amplitude of daily temperature fluctuations helps to explain seasonal forcing of DENV transmission at locations where average temperature does not vary seasonally and mosquito abundance is not associated with dengue incidence. Mosquitoes lived longer and were more likely to become infected under moderate temperature fluctuations, which is typical of the high DENV transmission season than under large temperature fluctuations, which is typical of the low DENV transmission season. Our findings reveal the importance of considering short-term temperature variations when studying DENV transmission dynamics.
机译:关于昆虫种群传播病原体能力的大多数研究仅考虑恒定温度,而不考虑可能影响载体-病原体相互作用的现实的每日温度波动。在这里,我们显示昼夜温度范围(DTR)影响埃及伊蚊传播登革热病毒(DENV)的两个重要参数。在两个使用不同DENV血清型的独立实验中,蚊子对病毒感染的敏感性较低,并且在相同的平均温度下,在较大的DTR下蚊子死亡更快。与中度DTR(10℃)或恒温相比,大DTR(20℃)降低了中肠感染的可能性,但没有降低病毒外在潜伏期(EIP)的持续时间。热力学模型预测,在平均温度<18℃时,DENV传输随DTR的增加而增加,而在平均温度> 18℃时,较大的DTR会降低DENV的传输。 DTR对Ae的负面影响。埃及人的生存表明,较大的温度波动将通过EIP和传染性预期降低媒介生存的可能性。每日温度波动幅度的季节性变化有助于解释在平均温度没有季节性变化且蚊子丰度与登革热发病率无关的位置上的DENV传播的季节性强迫。蚊子的寿命更长,并且在中等温度波动下(高DENV传播季节的典型特征)比在较大温度波动下(低DENV传播季节的典型特征)更容易被感染。我们的发现揭示了在研究DENV传输动力学时考虑短期温度变化的重要性。

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  • 作者单位

    Department of Virology, Institut Pasteur, 75724 Paris Cedex 15, France;

    Center for Infectious Disease Dynamics, Department of Entomology, Pennsylvania State University, University Park, PA 16802;

    Department of Virology, Institut Pasteur, 75724 Paris Cedex 15, France Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand;

    Department of Entomology, University of California, Davis, CA 95616;

    Wadsworth Center, New York State Department of Health, Slingerlands, NY 12159;

    School of Public Health, State University of New York at Albany, Albany, NY 12237 Center for Infectious Disease Dynamics, Department of Entomology, Pennsylvania State University, University Park, PA 16802;

    rnDepartment of Entomology, University of California, Davis, CA 95616 Fogarty International Center, National Institutes of Health, Bethesda, MD 20892;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    arbovirus; climate; vectorial capacity;

    机译:虫媒病毒;气候;载体能力;

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