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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation
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Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation

机译：T细胞上趋化因子受体CXCR3的表达影响效应子和记忆CD8 T细胞生成之间的平衡

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摘要

Killer T cells, also known as CD8 T cells, are essential for protection against viruses and many other intracellular pathogens. In response to an infection, pathogen-specific CD8 T cells rapidly proliferate and differentiate into a heterogeneous population of effector cells, the majority of which undergo apoptosis after the infection is controlled. However, a small fraction of the effector cells survive, becoming self-renewing and long-lived memory T cells that provide rapid protection against subsequent challenges from the same pathogen. Be-
机译：杀伤性T细胞，也称为CD8 T细胞，对于防御病毒和许多其他细胞内病原体至关重要。响应感染，病原体特异性CD8 T细胞迅速增殖并分化为异质效应细胞群，在控制感染后，大多数效应细胞会发生凋亡。然而，一小部分效应细胞可以存活，成为自我更新和长寿的记忆T细胞，可为来自同一病原体的后续攻击提供快速保护。是-

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    Joyce K. Hu; Takashi Kagari; Jonathan M. Clingan; Mehrdad Matloubian;

  • 作者单位

    Division of Rheumatology, Department of Medicine, and Rosalind Russell Medical Research Center for Arthritis,Graduate Program in Biomedical Sciences, University of California, San Francisco, CA 94143;

    Division of Rheumatology, Department of Medicine, and Rosalind Russell Medical Research Center for Arthritis;

    Division of Rheumatology, Department of Medicine, and Rosalind Russell Medical Research Center for Arthritis,Graduate Program in Biomedical Sciences, University of California, San Francisco, CA 94143;

    Division of Rheumatology, Department of Medicine, and Rosalind Russell Medical Research Center for Arthritis;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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