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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus
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Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus

机译：类固醇生成因子1指导程序调节饮食诱导的下丘脑内侧腹核的生热和瘦素作用

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摘要

The transcription factor steroidogenic factor 1 (5F-1) is exclusively expressed in the brain in the ventral medial hypothalamic nucleus (VMH) and is required for the development of this nucleus. However, the physiological importance of transcriptional programs regulated by SF-1 in the VMH is not well defined. To delineate the functional significance of SF-1 itself in the brain, we generated pre-and postnatal VMH-specific SF-1 KO mice. Both models of VMH-specific SF-1 KO were susceptible to high fat diet-induced obesity and displayed impaired thermogenesis after acute exposure to high fat diet. Furthermore, VMH-specific SF-1 KO mice showed significantly decreased LepR expression specifically in the VMH, leading to leptin resistance. Collectively, these results indicate that SF-1 directs transcriptional programs in the hypothalamus relevant to coordinated control of energy homeostasis, especially after excess caloric intake.
机译：转录因子类固醇生成因子1（5F-1）仅在腹侧下丘脑内侧核（VMH）中在大脑中表达，并且是该核发育所必需的。但是，由SF-1调控的VMH转录程序的生理重要性尚不明确。为了描述SF-1本身在大脑中的功能意义，我们生成了出生前和出生后VMH特异性SF-1 KO小鼠。两种VMH特异性SF-1 KO模型均易受高脂饮食诱导的肥胖影响，并在急性接触高脂饮食后显示出生热受损。此外，VMH特异性SF-1 KO小鼠在VMH中显示出明显降低的LepR表达，从而导致瘦蛋白抵抗。总体而言，这些结果表明，SF-1指导下丘脑中的转录程序，与能量稳态的协调控制有关，尤其是在摄入过多热量后。

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    Ki Woo Kim; Liping Zhao; Jose Donato Jr.; Daisuke Kohno; Yong Xu; Carol F. Elias; Charlotte Lee; Keith L. Parker; Joel K. Elmquist;

  • 作者单位

    Divisions of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390,Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

    Transgenic Animal Center, National Institute of Biological Science, Beijing 102206, China;

    Divisions of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390;

    Divisions of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390,Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

    Divisions of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390,Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

    Divisions of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390,Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

    Divisions of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390,Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

    Divisions of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390;

    Divisions of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390,Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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