Reductive DNA damage from ionizing radiation

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Reductive DNA damage from ionizing radiation

机译：电离辐射引起的还原性DNA损伤

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Ionizing radiation is known to cause mutations and cell death through oxidative DNA damage but little is known about the effects of reductive DNA damage, or breaks in the DNA double helix caused by the reduction of weakly-bound electrons. Previous experiments have shown that a shortlived species of electron produced in liquid water under ionizing radiation, the so-called "prehydrated" electron, causes chemical bond breaks in DNA bases; and theoretical work has suggested that such bond breaks may damage DNA in a fashion similar to oxidative damage.

机译：众所周知，电离辐射会通过氧化性DNA损伤而导致突变和细胞死亡，但对还原性DNA损伤或弱结合电子的减少导致的DNA双螺旋断裂的影响知之甚少。先前的实验表明，液态水在电离辐射下产生的一种短暂电子，即所谓的“预水合”电子，会导致DNA碱基的化学键断裂。理论研究表明，这种键断裂可能以类似于氧化损伤的方式损伤DNA。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2011年第29期|p.11728|共1页
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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4. DEVELOPMENT OF CURCUMIN-BASED THERAPIES FOR COMBATING DNA-DAMAGE DUE TO IONIZING SPACE RADIATION [C] . M. G. OToole, P. S. Soucy, R. M. Henderson, ISS Research and Development Conference . 2013

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5. Aspects of radiation damage in DNA oligomers: Studies of the direct effects of ionizing radiation: Effects of specific nucleobase lesions on nuclease P1-DNA interaction. [D] . Falcone, Joseph Michael. 1998

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6. Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations [O] . Konstantinos P. Chatzipapas, Panagiotis Papadimitroulas, Dimitris Emfietzoglou, 2020

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Reductive DNA damage from ionizing radiation

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