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Caloric restriction and female infertility

机译:热量限制和女性不育

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摘要

Age-associated decline in the quality of eggs women produce can lead to infertility, miscarriage, and fetuses with genetic disorders. Among the causes of poor egg quality are defects in chromosomal separation during meiotic cell division and clumping of mitochondria within the cytoplasm of eggs. Kaisa Selesniemi et al. (pp. 12319-12324) tested the effects of caloric restriction-a dietary regimen that has been shown to slow the ravages of age in mice-on the quality of mature eggs produced by aging mice. The authors report that 12-month-old female mice that were maintained on a 40% calorie-restricted diet from 3.5 months of age produced eggs of noticeably better quality than did age-matched mice fed a normal diet.
机译:与年龄相关的妇女生产的鸡蛋质量下降会导致不育,流产和遗传疾病的胎儿。造成鸡蛋质量差的原因之一是减数分裂细胞分裂过程中染色体分离缺陷以及卵细胞内线粒体结块。 Kaisa Selesniemi等。 (pp.12319-12324)测试了热量限制(一种饮食方案已被证明可以减缓小鼠年龄的破坏)对衰老小鼠产生的成熟卵质量的影响。这组作者报告说,从3.5个月大起接受40%卡路里限制饮食的12个月大雌性小鼠产生的鸡蛋质量要比喂食正常饮食的同龄小鼠好得多。

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