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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Continuous dental replacement in a hyper-chisel tooth digging rodent
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Continuous dental replacement in a hyper-chisel tooth digging rodent

机译：在超凿齿式啮齿动物中连续更换牙齿

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摘要

Contrary to their reptilian ancestors, which had numerous dental generations, mammals are known to usually develop only two generations of teeth. However, a fe.w mammal species have acquired the ability to continuously replace their dentition by the constant addition of supernumerary teeth moving secondarily toward the front of the jaw. The resulting treadmill-like replacement is thus horizontal, and differs completely from the vertical dental succession of other mammals and their extinct relatives. Despite the developmental implications and prospects regarding the origin of supernumerary teeth, this striking innovation remains poorly documented. Here we report another case of continuous dental replacement in an African rodent, Heliophobius argenteo-cinereus, which combines this dental system with the progressive eruption of high-crowned teeth. The escalator-like mechanism of Heliophobius constitutes an original adaptation to hyper-chisel tooth digging involving high dental wear. Comparisons between Heliophobius and the few mammals that convergently acquired continuous dental replacement reveal that shared inherited traits, including dental mesial drift, delayed eruption, and supernumerary molars, comprise essential prerequisites to setting up this dental mechanism. Interestingly, these dental traits are present to a lesser extent in humans but are absent in mouse, the usual biological model. Consequently, Heliophobius represents a suitable model to investigate the molecular processes leading to the development of supernumerary teeth in mammals, and the accurate description of these processes could be a significant advance for further applications in humans, such as the regeneration of dental tissues.
机译：与具有许多牙齿世代的爬行动物祖先相反，已知哺乳动物通常只发育两代牙齿。然而，少数哺乳动物已经获得了通过不断增加第二齿向颌骨前部移动而不断替换其牙列的能力。因此，所得到的跑步机状替换物是水平的，完全不同于其他哺乳动物及其已灭绝的亲属的垂直牙齿排列。尽管关于多余牙齿的起源具有发展意义和前景，但这种惊人的创新仍然鲜有记载。在这里，我们报告了另一例在非洲啮齿动物Heliophobius argenteo-cinereus中连续进行牙齿替换的案例，该案例将这种牙齿系统与高加冠牙齿的逐渐萌发结合在一起。 Heliophobius的类似自动扶梯的机构构成了对涉及高牙齿磨损的超凿子牙齿挖掘的原始适应。比较Heliophobius和少数会持续获得连续牙齿替换的哺乳动物，发现共有的遗传特征，包括牙齿间膜漂移，延迟喷发和多余的臼齿，是建立这种牙齿机制的必要先决条件。有趣的是，这些牙齿特征在人类中的存在程度较小，但在小鼠（通常的生物学模型）中却不存在。因此，Heliophobius代表了一个合适的模型，用于研究导致哺乳动物中多余牙齿发展的分子过程，并且这些过程的准确描述对于在人类中的进一步应用（例如牙齿组织的再生）可能具有重要的意义。

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    Helder Gomes Rodrigues; Pauline Marangoni; Radim Sumbera; Paul Tafforeau; Wim Wendelen; Laurent Viriot;

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    Team "Evo-Devo of Vertebrate Dentition," Institut de Genomique Fonctionnelle de Lyon, Universite de Lyon, Unite Mixte de Recherche 5242, Centre National de la Recherche Scientif ique, Universite Claude Bernard de Lyon 1, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France;

    Team "Evo-Devo of Vertebrate Dentition," Institut de Genomique Fonctionnelle de Lyon, Universite de Lyon, Unite Mixte de Recherche 5242, Centre National de la Recherche Scientif ique, Universite Claude Bernard de Lyon 1, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France;

    Department of Zoology, Faculty of Science, University of South Bohemia, Ceske Budejovice 37005, Czech Republic;

    European Synchrotron Radiation Facility, 38043 Grenoble Cedex, France;

    Vertebrate Section, Zoology Department, Royal Museum for Central Africa, B-3080 Tervuren, Belgium;

    Team "Evo-Devo of Vertebrate Dentition," Institut de Genomique Fonctionnelle de Lyon, Universite de Lyon, Unite Mixte de Recherche 5242, Centre National de la Recherche Scientif ique, Universite Claude Bernard de Lyon 1, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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