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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis
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Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis

机译：线粒体抗病毒信号蛋白（MAVS）监测共生细菌并诱导免疫反应，从而预防实验性结肠炎

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摘要

RIG-I-like receptors (RLRs) activate host innate immune responses against virus infection through recruiting the mitochondrial adaptor protein MAVS (also known as IPS1, VISA, or CARDIF). Here we show that MAVS also plays a pivotal role in maintaining intestinal homeostasis. We found that MAVS knockout mice developed more severe mortality and morbidity than WT animals in an experimental model of colitis. Bone marrow transplantation experiments revealed that MAVS in cells of nonhematopoietic origin plays a dominant role in the protection against colitis. Importantly, RNA species derived from intestinal commensal bacteria activate the RIG-I-MAVS pathway to induce the production of multiple cytokines and antimicrobial peptides, including IFN-p and Regllly. These results unveil a previously unexplored role of MAVS in monitoring intestinal commensal bacteria and maintaining tissue homeostasis.
机译：RIG-I样受体（RLR）通过募集线粒体衔接蛋白MAVS（也称为IPS1，VISA或CARDIF）激活针对病毒感染的宿主固有免疫反应。在这里，我们显示MAVS在维持肠道动态平衡方面也起着关键作用。我们发现在结肠炎的实验模型中，MAVS基因敲除小鼠比野生型动物出现了更严重的死亡率和发病率。骨髓移植实验表明，非造血来源的细胞中的MAVS在预防结肠炎中起主要作用。重要的是，源自肠道共生细菌的RNA物种激活RIG-I-MAVS途径，从而诱导多种细胞因子和抗菌肽（包括IFN-p和Regllly）的产生。这些结果揭示了MAVS在监测肠道共生细菌和维持组织稳态方面的前所未有的作用。

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