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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria
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An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

机译:一种完全特异性的I型A激酶锚定蛋白,可在线粒体中隔离两个分子的蛋白激酶A

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摘要

Within the cell, cAMP acts as a second messenger that relays signals initiated by other factors (e.g., hormones) to activate an enzyme known as protein kinase A (PKA). Upon activation, PKA adds a phosphate group to various proteins, thereby initiating a wide range of signaling events in mammalian cells. Prior to activation by cAMP, PKA exists as a holoenzyme consisting of two regulatory (R) subunits and two catalytic (C) subunits, with the R subunits preventing the C subunits from phosphorylating their targets.
机译:在细胞内,cAMP充当第二信使,该信使传递其他因素(例如激素)引发的信号,从而激活一种称为蛋白激酶A(PKA)的酶。激活后,PKA将磷酸基团添加到各种蛋白质中,从而在哺乳动物细胞中引发各种信号事件。在被cAMP激活之前,PKA以全酶形式存在,由两个调节(R)亚基和两个催化(C)亚基组成,其中R亚基可防止C亚基磷酸化其靶标。

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    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195;

    Biotechnology Center of Oslo and Center for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, University of Oslo, N-0317 Oslo, Norway;

    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195;

    Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61822;

    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195;

    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195;

    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195;

    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093;

    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;

    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093;

    Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61822,Howard Hughes Medical Institute, Department of Physics and Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, IL 61822;

    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195;

    Biotechnology Center of Oslo and Center for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, University of Oslo, N-0317 Oslo, Norway;

    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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