...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Investment in rapid growth shapes the evolutionary rates of essential proteins
【24h】

Investment in rapid growth shapes the evolutionary rates of essential proteins

机译：快速增长的投资决定了必需蛋白质的进化速率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Proteins evolve at very different rates and, most notably, at rates inversely proportional to the level at which they are produced. The relative frequency of highly expressed proteins in the proteome, and thus their impact on the cell budget increases steeply with growth rate. The maximal growth rate is a key life-history trait reflecting trade-offs between rapid growth and other fitness components. We show that the maximal growth rate is weakly affected by genetic drift. The negative correlation between protein expression levels and evolutionary rate and the positive correlation between expression levels of highly expressed proteins and growth rates, suggest that investment in growth affects the evolutionary rate of proteins, especially the highly expressed ones. Accordingly, analysis of 61 families of orthologs in 74 pro-teobacteria shows that differences in evolutionary rates between lowly and highly expressed proteins depend on maximal growth rates. Analyses of complexes with key roles in bacterial growth and strikingly different expression levels, the ribosome and the replisome, confirm these patterns and suggest that the growth-related sequence conservation is associated with protein synthesis. Maximal growth rates also shape protein evolution in the other bacterial clades. Long-branch attractions associated with this effect might explain why clades with persistent history of slow growth are attracted to the root when the tree of prokaryotes is inferred using highly, but not lowly, expressed proteins. These results indicate that reconstruction of deep phylogenies can be strongly affected by maximal growth rates, and highlight the importance of life-history traits and their physiological consequences for protein evolution.
机译：蛋白质以非常不同的速率进化，最显着的是，其进化速率与蛋白质的产生水平成反比。蛋白质组中高表达蛋白质的相对频率，因此它们对细胞预算的影响随生长速率急剧增加。最大增长率是反映生命快速增长与其他适应性因素之间取舍的关键生命历史特征。我们表明最大增长率受遗传漂移的影响很小。蛋白质表达水平与进化速率之间的负相关以及高表达蛋白质表达水平与生长率之间的正相关，表明对生长的投资会影响蛋白质尤其是高表达蛋白质的进化速率。因此，对74个变形细菌中61个直系同源物家族的分析表明，低表达和高表达蛋白之间进化速率的差异取决于最大生长速率。对在细菌生长中具有关键作用且表达水平显着不同的复合体，核糖体和复制体的分析证实了这些模式，并表明与生长相关的序列保守性与蛋白质合成有关。最大生长速率也会影响其他细菌进化枝中蛋白质的进化。与这种效应相关的长分支吸引力可能可以解释为什么当使用高表达而不是低表达的蛋白质推断出原核生物树时，具有缓慢生长持续历史的进化枝会吸引到根部。这些结果表明，最大的生长速率可能强烈影响深系统发育的重建，并突出了生命历史特征及其对蛋白质进化的生理影响的重要性。

著录项

  • 来源
  • 作者

    Sara Vieira-Silva; Marie Touchon; Sophie S. Abby; Eduardo P. C. Rocha;

  • 作者单位

    Microbial Evolutionary Genomics, Departement Genomes et Genetique, Institut Pasteur, F-75015 Paris, France,Centre National de la Recherche Scientifique, Unite de Recherche Associee (URA) 2171, F-75015 Paris, France;

    Microbial Evolutionary Genomics, Departement Genomes et Genetique, Institut Pasteur, F-75015 Paris, France,Centre National de la Recherche Scientifique, Unite de Recherche Associee (URA) 2171, F-75015 Paris, France;

    Microbial Evolutionary Genomics, Departement Genomes et Genetique, Institut Pasteur, F-75015 Paris, France,Centre National de la Recherche Scientifique, Unite de Recherche Associee (URA) 2171, F-75015 Paris, France;

    Microbial Evolutionary Genomics, Departement Genomes et Genetique, Institut Pasteur, F-75015 Paris, France,Centre National de la Recherche Scientifique, Unite de Recherche Associee (URA) 2171, F-75015 Paris, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    evolutionary rate heterogeneity; microbial growth; tree of life;

    机译：进化率异质性微生物生长生命之树;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号